ENHANCEMENT OF DOPAMINE-INDUCED STIMULATION OF PANCREATIC SECRETION BY 5-DIMETHYLDITHIO-CARBAMYLPICOLINIC ACID (YP-279), A DOPAMINE β-HYDROXYLASE INHIBITOR
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概要
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Effect of 5-dimethyldithiocarbamylpicolinic acid (YP-279), a dopamine β-hydroxylase inhibitor, on the secretion of pancreatic juice induced by dopamine was investigated in preparations of the isolated blood-perfused canine pancreas. Either a single injection (300 μg) or an infusion (100 μg/min) of YP-279 intra-arterially (i.a.) caused no change in the outflow of the pancreatic juice, but the secretagogue effect of dopamine (1-10 μg, i.a.) was enhanced by the infusion of YP-279 (100 μg/min, i.a.) for 60 min. The previous conclusion obtained with fusaric acid was confirmed as follows; the dopamine β-hydroxylase activity controls the dopaminergic mechanism of the pancreatic secretion.
- 社団法人 日本薬理学会の論文
著者
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IWATSUKI Kazuhiko
Department of Pharmacology, Shinshu University School of Medicine
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HASHIMOTO Koroku
Department of Pharmacology, Tokyo University
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Hashimoto Koroku
Department Of Pharmacology Faculty Of Medicine University Of Tokyo:iatrochemical Institute Of The Ph
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