Effects of DN-9693, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion in dogs.
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概要
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The effects of DN-9693, a synthesized phosphodiesterase inhibitor, on the secretion of pancreatic juice were investigated in preparations of the isolated and blood-perfused dog pancreas. DN-9693 injected intraarterially caused a dose-dependent increase in the secretion of pancreatic juice and decrease in the perfusion pressure. The threshold doses to increase the pancreatic secretion and to decrease the perfusion pressure were about 100 μg and 1 μg, respectively. Thus, the secretory response was less effective than the vascular response. The secretory activity of DN-9693 (0.3 mg) was approximately equal to that of 0.03 mg of 3-isobutyl-1-methylxanthine, 0.5 mg of papaverine, 5 mg of theophylline, 0.08 units of secretin and 0.2 units of cholecystokinin. The concentration of bicarbonate in the pancreatic juice induced by DN-9693 was increased, but protein concentration was not. DN-9693-induced pancreatic secretion was not modified by pretreatments with phentolamine, propranolol, atropine, sulpiride and cimetidine. Secretin-induced pancreatic secretion was significantly potentiated by infusion of DN-9693 (10 μg/min), but cholecystokinin-induced one was not. From these results, it is concluded that DN-9693 may produce an increase in pancreatic secretion by acting directly on the pancreatic exocrine gland of the dog, which might be mediated through an increase of intracellular cyclic AMP concentration by inhibiting phosphodiesterase activity.
- 公益社団法人 日本薬理学会の論文
著者
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HORIUCHI Akira
Department of Pharmacology, Shinshu University School of Medicine
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Horiuchi Akira
Department Of Chemistry Rikkyo (st. Paul's) University
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Homma Norio
Department Of Research And Development Hokkaido Electric Power Co. Inc.
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Iwatsuki Kazuhiko
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Department of Pharmacology, Shinshu University School of Medicine
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YONEKURA Hiroaki
Department of Pharmacology, Shinshu University School of Medicine
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HARUTA Kouichi
Department of Pharmacology, Shinshu University School of Medicine
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HOMMA Norio
Department of Pharmacology, Shinshu University School of Medicine
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HOMMA NORIO
Department of Industrial Chemistry, Nagoya Institute of Technology
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