Pharmacological Features of Vascular Responses of Isolated Dog and Monkey Linqual Arteries to Vasoactive Substances.
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概要
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Using a perfusion technique of isolated vessels, vasoconstrictor responses to alpha adrenoceptor agonists (norepinephrine [NE], phenylephrine [PE], clonidine, xylazine and tyramine) and KCl were investigated in isolated, perfused dog and monkey lingual arteries. A stainless steel cannula was inserted into the lingual artery segment and perfused with Krebs-Henseleit solution at a constant flow rate. In dog lingual avteries, the agonists induced vasoconstrictions with the following order of potency: NE > PE > tyramine >> clonidine > xylazine > KCl. In monkey preparations, the order was NE > PE >> clonidine ≥ tyramine > xylazine > KCl. In both preparations, NE- and PE-induced constrictions were blocked by bunazosin (an alpha-1 adrenoceptor antagonist), but not influenced by midaglizole (a potent alpha-2 antagonist). Diltiazem (a Ca entry blocker) significantly attenuated NE-induced vasoconstrictions in dog lingual arteries, but did not significantly influence these in monkey preparations. These results suggest that: [1] these arteries contain mostly alpha-1 but scarcely any alpha-2 adrenoceptors; [2] in dog preparations, tyramine induced a marked vasoconstriction which may contribute to investigation on the mechanisms of catecholamine releases from sympathetic nerve terminals; and [3] different blocking effects of diltiazem may indicate that extracellular Ca<SUP>++</SUP> influx may have varying degrees of importance in alpha-1 adrenoreceptor-mediated constrictions in different species, although participation of an intracellular mechanism might not be ruled out.
- 公益社団法人 日本薬理学会の論文
著者
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Department of Pharmacology, Medical Faculty, University of Banja Luka
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Skrbic Ranko
Department of Pharmacology, Medical Faculty, University of Banja Luka
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