SELECTIVE ABOLITION OF Ca-DEPENDENT RESPONSES OF SMOOTH AND CARDIAC MUSCLES BY FLUNARIZINE
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of flunarizine on the Ca-dependent responses was compared with that of verapamil in isolated smooth and cardiac muscles. Flunarizine at a small dose shifted to the right the dose-response curve for Ca<SUP>2+</SUP> of the phasic contraction due to electric stimuli in rabbit basilar strips, while in a large dose, flunarizine reduced the maximum tension and slope of the dose-response curve. The high K<SUP>+</SUP>-induced vasoconstriction of the rabbit basilar artery was inhibited by flunarizine. However, the action of flunarizine was about 30 times slower than findings with verapamil. The spontaneous activity of the rat portal vein was less susceptible to flunarizine, whereas that of rat uterus was completely inhibited by flunarizine. Flunarizine possessed moderate negative chronotropic and inotropic actions on the right atria and papillary muscles of the rabbit. Our experiments indicate that flunarizine is selective in antagonizing Ca-dependent contraction of the rabbit basilar artery, probably by blockade of the transmembrane Ca. It is also possible that the slow onset of action and nonsurmountable antagonism produced by flunarizine is due to other pharmacological interventions such as delayed effect of metabolites, stabilizing action or tight binding on the cell membrane of vascular smooth muscles.
- 社団法人 日本薬理学会の論文
著者
-
Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
-
NAKAYAMA Koichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
関連論文
- Involvement of Cyclooxygenase-2 in Synergistic Effect of Cyclic Stretching and Eicosapentaenoic Acid on Adipocyte Differentiation
- Expression of Xeroderma Pigmentosum Group G (XPG) in Sporadic Breast Carcinoma
- ATTENUATION OF THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS BY CHRONIC ORAL ADMINISTRATION OF EICOSAPENTAENOIC ACID
- Role of Na^+/Ca^ Exchanger-Mediated Ca^ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
- (+)-[^3H] Isradipine and [^3H] Glyburide Bindings to Heart and Lung Membranes From Rats With Monocrotaline-Induced Pulmonary Hypertension
- Elucidation With the Protease α-Chymotrypsin of the Inhibitory Modulating Action of Endogenous Neuropeptide Y Over Sympathetic Neurotransmission in Rat Vas Deferens
- INHIBITORY EFFECTS OF HISTAMINE ON CONTRACTION INDUCED BY TRANSMURAL STIMULATION IN RAT VAS DEFERENS
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. I. : Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.
- Involvement of α_2-Adrenergic Receptors in the Vagal Reflex-Induced Tracheal Constriction
- INHIBITION OF THE VAGAL REFLEX-INDUCED TRACHEAL CONSTRICTION BY PSYCHOTROPIC DRUGS
- Mechanisms of Increased Responses of the Aorta to α-Adrenoceptor Agonists in Streptozotocin-Induced Diabetic Rats
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. III. ACTIONS ON CARDIOVASCULAR SYSTEM AND ACUTE TOXICITY
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. II. AGONISTIC AND ANTAGONISTIC ACTIONS ON α-ADRENOCEPTORS IN VARIOUS SMOOTH MUSCLE PREPARATIONS
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. I. A COMPARISON OF THE EFFECT ON PRE- AND POSTSYNAPTIC α-ADRENOCEPTORS IN THE RAT VAS DEFERENS
- Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor
- Further Studies Concerning Possible Transmitters from NANC Nerves in the Circular Muscle of the Rat Stomach Fundus
- PLATELET ACTIVATING FACTOR : LACK OF DIRECT CARDIAC ACTION AND POSSIBLE TRANSMITTER RELEASE FROM CARDIAC SYMPATHETIC NERVE ENDINGS AT HIGH CONCENTRATIONS. ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES WITH GUINEA PIG VENTRICULAR MYOCARDIUM
- Effects of Calmodulin Antagonist (W-7) on Phorbol Ester (PMA)-induced Contractile Response in Isolated Rat Aorta
- Effect of phorbol 12, 13-dibutyrate on smooth muscle tone in rat stomach fundus
- Diabetes-related changes in contractile responses of stomach fundus to endothelin-1 in streptozotocin-induced diabetic rats
- Contractile Potentiation by Endothelin-1 Involves Protein Kinase C-δ Activity in the Porcine Coronary Artery
- Impedance Cardiography for the Assessment of Cardiac Function During Exercise : SYMPOSIUM ON EXERCISE TESTINGS OF HEART DISEASE
- Glibenclamide-Sensitive Hypotension Produced by Helodermin Assessed in the Rat
- Flow-Dependent Regulation of Nitric Oxide Formation in the Isolated Canine Mesenteric Arterial Bed
- Flow Regulates Vasodilator Responses to Acetylcholine in the Isolated Canine Mesenteric Arterial Bed
- Differential involvement of α_1-adrenoceptors in vasoconstrictor responses to cooling in mouse plantar arteries in vitro and in vivo
- Role of Na+/Ca2+ Exchanger–Mediated Ca2+ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
- Distinct Roles of Protein Kinase C Isoforms in Myogenic Constriction of Rat Posterior Cerebral Arteries
- POTENTIATION BY BOVINE SERUM ALBUMIN (BSA) OF ENDOTHELIUM-DEPENDENT VASODILATOR RESPONSE TO ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE (AGEPC)
- Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1
- Differences in cell kinetic changes among renal cancer cell lines treated with interferon-α
- The effect of papaverine on morphologic differentiation,proliferation and invasive potential of human prostatic cancer LNCaP cells
- Evidence for Protein Kinase C-Mediated Activation of Rho-Kinasein a Porcine Model of Coronary Artery Spasm
- RENAL MICROSOMAL N-NITROSODIMETHYLAMINE DEMETHYLASE DETERMINED BY A SENSITIVE RADIOMETRIC METHOD
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. II. : Hepatotoxicity by the simultaneous administration of several drugs and nitrite.
- ^Mg (d,p)^Mg Reactions at 3.1 and 3.5 MeV
- Involvement of Different Activator Ca^ in the Rate-Dependent Stretch-Induced Contractions of Canine Basilar Artery
- EFFECTS OF HYPOXIA AND REOXYGENATION ON TISSUE ATP LEVEL AND ELECTRICAL AND MECHANICAL FUNCTION OF ISOLATED GUINEA PIG VENTRICULAR MUSCLES.
- EFFECTS OF HYPOXIA AND METABOLIC INHIBITORS ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF ISOLATED GUINEA PIG PAPILLARY MUSCLES
- ELECTROPHYSIOLOGICAL EFFECTS OF A NEW ANTIARRHYTHMIC AGENT, LORCAINIDE, ON THE ISOLATED CARDIAC MUSCLE FIBER AS COMPARED WITH DISOPYRAMIDE
- Facilitation of L-type Ca^ Currents by Fluid Flow in Rabbit Cerebral Artery Myocytes
- Effects of L-Tryptophan on the Effects of Antitussives
- Effects of Double-enkephalin (Biphalin), an Enkephalin Analogue, on Respiration and the Cough Reflex in Rats
- Effect of Diabetes on the Morphine-Induced Inhibition of Gastrointestinal Tranist
- Functional Studies on Blockade by Neosurugatoxin of Nicotinic Receptors in Nitroxidergic and Sensory Nerve Terminals and Intramural Ganglionic Cells
- NEGATIVE CHRONOTROPIC EFFECT OF DIBUTYRYL CYCLIC AMP ON THE CULTURED CHICK EMBRYONIC HEART CELLS AND THE PROLONGATION OF THE ACTION POTENTIAL DURATION
- THE MECHANISM OF AGGRAVATION OF INDOMETHACIN-INDUCED GASTRIC ULCERS BY ADRENALECTOMY IN THE RAT
- Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
- EFFECTS OF SMOOTH MUSCLE STIMULANTS ON I-ISOPRENALINE-β-ADRENOCEPTOR INTERACTION IN TAENIA FROM GUINEA PIG CAECUM
- EFFECTS OF VARIOUS DRUGS AND VAGOTOMY ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN THE RAT
- INHIBITORY ALPHA-ADRENERGIC ACTION OF PHENYLEPHRINE IN GUINEA PIG TAENIA CAECUM
- EFFECTS OF COCAINE ON Ca-MOBILITY IN MICROSOMAL FRACTION FROM RAT VAS DEFERENS
- EFFECTS OF ACETYLCHOLINE AND HISTAMINE ON MECHANICAL ACTIVITY OF RABBIT TAENIA COLI, Ca-INCORPORATION AND Ca-RELEASE IN ITS MICROSOMAL FRACTION
- NONSPECIFIC RELAXATION OF INTESTINAL SMOOTH MUSCLE INDUCED BY ANTISPASMODICS AND MOVEMENT OF CALCIUM IONS
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY IN DEPOLARIZED TAENIA CAECUM OF GUINEA PIG
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON TISSUE CONCENTRATIONS OF HIGH ENERGY PHOSPHATES AND MECHANICAL ACTIVITY OF NORMAL POLARIZED AND DEPOLARIZED INTESTINAL SMOOTH MUSCLES FROM GUINEA PIG
- POSSIBLE ROLE OF ENDOTHELIUM IN THE VASODILATOR RESPONSE OF RAT THORACIC AORTA TO PLATELET ACTIVATING FACTOR (PAF)
- STUDIES ON THE HYPOTENSIVE EFFECTS OF PLATELET ACTIVATING FACTOR (PAF, 1-o-ALKYL-2-ACETYL-sn-GLYCERYL-3-PHOSPHORYLCHOLINE) IN RATS, GUINEA PIGS, RABBITS, AND DOGS
- ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES ON THE CARDIAC EFFECTS OF A HISTAMINE H_2 RECEPTOR ANTAGONIST, CIMETIDINE, IN THE ISOLATED GUINEA PIG MYOCARDIUM
- EVIDENCE FOR A DIRECT ACTION OF X-537A ON THE CARDIAC PLASMA MEMBRANE AS AN IONOPHORE
- Preservation of Endothelium-Dependent Vascular Relaxation in Cholesterol-Fed Mice by the Chronic Administration of Prazosin or Pravastatin
- INHIBITION BY PROPRANOLOL OF HIGH POTASSIUM-INDUCED CONTRACTIONS IN THE RAT VAS DEFERENS
- A COMPARATIVE STUDY OF CHANGES IN INNERVATION AND DEVELOPMENT OF SUPERSENSITIVITY IN THE RAT VAS DEFERENS AFTER VARIOUS PROCEDURES
- EFFECTS OF VARIOUS DRUGS AND EXTRINSIC DENERVATION ON THE NON-ADRENERGIC INHIBITORY NEURONS IN THE RAT STOMACH
- RENAL TOXICITY OF ADENOSINE 3', 5'-CYCLIC MONOPHOSHATE IN MICE.
- ACUTE TOXICITY OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE
- Isobaric Analogue Resonances in ^Al Studied with the ^Mg (p, p) and ^Mg (p, γ) Reactions
- CARDIOTONIC EFFECT OF PHTHALAZINOL (EG-626) IN THE ISOLATED GUINEA PIG MYOCARDIUM : MECHANICAL AND ELECTROPHYSIOLOGICAL STUDY
- Effects of DX-9065a, an Inhibitor of Factor Xa, on Ellagic Acid-Induced Plantar Skin Thrombosis Assessed in Tetrodotoxin- and N^ω -Nitro-L-Arginine- Treated Rats
- ANTIARRHYTHMIC ACTIVITY OF DEXTRO- AND LEVO-ISOMERS OF 5-METHYL-8-(2-HYDROXY-3-T-BUTYLAMINO-PROPOXY) COUMARIN HYDROCHLORIDE (BUCUMOLOL), A β-ADRENERGIC BLOCKING AGENT, ON ACONITINE-INDUCED ATRIAL AND OUABAIN-INDUCED VENTRICULAR ARRHYTHMIAS IN DOGS
- PHARMACOLOGY OF dl-5-METHYL-8-(2-HYDROXY-3-t-BUTYLAMINOPROPOXY) COUMARIN HYDROCHLORIDE (CS-359), A NEW β-ADRENERGIC BLOCKING AGENT
- EFFECTS OF 15(S)-15-METHYL-PGE2 METHYL ESTER ON HEALING OF CHRONIC GASTRIC AND DUODENAL ULCERS IN RATS
- DESENSITIZATION OF GUINEA PIG TRACHEAL MUSCLE PREPARATION TO BETA-ADRENERGIC STIMULANTS BY A PRECEDING EXPOSURE TO A HIGH DOSE OF CATECHOLAMINES
- INFLUENCE OF SURGICAL SYMPATHECTOMY ON GASTRIC SECRETION AND ULCERATION IN RATS
- GASTRIC ACID SECRETION IN BEAGLE DOGS USING INTRAMUSCULAR INJECTION OF STIMULANTS
- RHYTHMIC CONTRACTIONS INDUCED BY VAGOTOMY IN THE FUNDUS OF RAT STOMACH
- EFFECTS OF ANISOTROPINE METHYLBROMIDE (VALPIN®) AND ITS MIXTURE WITH SULPYRINE ON VOCALIZATION RESPONSE AND SPASM OF INTESTINE INDUCED BY ACETYLCHOLINE IN DOGS
- Two Distinct Effects of cGMP on Cytosolic Ca^ Concentration of Rat Pancreatic β-Cells
- SELECTIVE ABOLITION OF Ca-DEPENDENT RESPONSES OF SMOOTH AND CARDIAC MUSCLES BY FLUNARIZINE
- ROLE OF CALCIUM IONS AND ENDOTHELIUM IN THE STRETCH-INDUCED CONTRACTILE ACTIVATION OF VASCULAR TISSUES
- EFFECTS OF COCAINE AND TETRAETHYLAMMONIUM ON THE SPIKE POTENTIALS AND CONTRACTIONS INDUCED BY TRANSMURAL STIMULATION IN THE RAT VAS DEFERENS
- EFFECTS OF OXIMES, DIACETYLMONOXIME, PYRIDINE-2-ALDOXIME, AND PYRIDINE-2-ALDOXIME METHOCHLORIDE, ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF GUINEA PIG CARDIAC VENTRICULAR MUSCLES
- POTENTIATION OF CARDIOVASCULAR EFFECTS OF CATECHOLAMINES BY A DIPHENYLALKANOLAMINE
- LACK OF PARALLELISM BETWEEN THE POSITIVE INOTROPIC EFFECTS OF VARIOUS CARDIAC STIMULANTS AND THEIR ACTIVITIES TO PRODUCE THE SLOW CHANNELS IN THE DEPOLARIZED MYOCARDIUM
- REGIONAL DIFFERENCES IN THE DISTRIBUTION OF CHOLINERGIC RECEPTORS IN THE RAT VAS DEFERENS
- THE EFFECT OF DENERVATION ON THE CYCLIC NUCLEOTIDES LEVELS OF THE VAS DEFFERENS
- TOXICOLOGICAL STUDIES ON THE CHLOROQUINE-MELANIN AFFINITY IN VIVO AND IN VITRO IN RELATION TO THE CHLOROQUINE RETINOPATHY
- ELECTROPHYSIOLOGICAL STUDY ON THE SO-CALLED SENSITIZING EFFECT OF HALOTHANE TO CATECHOLAMINES IN THE DOG CARDIAC MUSCLE
- A DECREASE IN ACETYLCHOLINE CONTENT OF THE RAT VAS DEFERENS AFTER SURGICAL DENERVATION
- NZ-105, a New 1,4-Dihydropyridine Derivative: Correlation between Dihydropyridine Receptor Binding and Inhibition of Calcium Uptake in Rabbit Aorta.
- Analysis of New Imidazoline Derivative-Induced Increase in the Maximum Response to Norepinephrine in the Rat Vas Deferens
- Primary Aldosteronism due to Unilateral Adrenal Microadenoma in an Elderly Patient: Efficacy of Selective Adrenal Venous Sampling
- Effects of Muscarinic Antagonists on Experimental Nasal Secretion in Guinea Pigs.
- TEA prevents the decline of the duration of the action potential in hypoxic cardiac muscle.
- Are .ALPHA.-adrenoceptors involved in positive inotropic effects of phenylephrine in chick ventricles?
- Further dopaminergic supersensitivity to dopamine agonists by subchronic administration of haloperidol in rats treated with colchicine.
- Effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine.
- Effects of Morphine on Responses of Nociceptive Ventrobasal Thalamic Neurons in Diabetic Rats.
- Changes in sensitivity of the rat stomach fundus to various drugs in streptozotocin-induced diabetic rats.
- Effects of histamine on neurally mediated contraction of canine tracheal smooth muscle.