EFFECTS OF SMOOTH MUSCLE STIMULANTS ON I-ISOPRENALINE-β-ADRENOCEPTOR INTERACTION IN TAENIA FROM GUINEA PIG CAECUM

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概要

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• An increase of intracellular cyclic AMP levels induced by 1-isoprenaline (1-Iso) was significantly depressed in coexistence with BuTMA or histamine, but not with KCl or BaCl<SUB>2</SUB>. An analysis of steady state data for d, l-[<SUP>3</SUP>H]-isoprenaline binding to single cells of taenia from guinea pig caecum in the presence of histamine or KCl by Scatchard plots was performed. The affinity of 1-Iso for β-adrenoceptor sites was decreased in the presence of histamine but not in the presence of KCl. These results suggest that the interaction of 1-Iso with the β-adrenoceptors is interfered with by histamine and butyltrimethylammonium, for which the specific receptors were postulated, but not with KCl and BaCl<SUB>2</SUB>, nonspecific smooth muscic stimulants. These phenomena demonstrate the heterotropic negative cooperativity among the heterogeneous receptors.

• 社団法人 日本薬理学会の論文

著者

• TAKAYANAGI Issei

  Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

• KASUYA YUTAKA

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

• KONDO Noriaki

  Department of Biological Siences, Graduate School of Sience, The University of Tokyo

• Takayanagi Issei

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo

• Kondo Noriaki

  Department Of Biological Sciences Graduate School Of Science The University Of Tokyo

• Kasuya Yutaka

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• KONDO Noriaki

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Unirersity of Tokyo

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