A DIFFERENCE IN PHARMACOLOGICAL PROPERTIES OF HISTAMINE RECEPTORS IN RABBIT AORTA AND BASILAR ARTERY
スポンサーリンク
概要
- 論文の詳細を見る
An interaction of Ca entry blockers, D600 and diltiazem, with histamine receptors was tested in rabbit aorta and basilar artery. D600 caused a parallel rightward shift of the concentration response curve for histamine. The slope values from Schild plot analysis in aorta were not different from unity. Dibenamine pretreatment caused reduction of maximum response to histamine in aorta. Such reduction was diminished markedly by the presence of D600 or chlorpheniramine in aorta but not in basilar artery. However, diltiazem did not influence the concentration response curve for histamine. These findings suggest that pharmacological property of histamine receptors in rabbit aorta is distinct from that in basilar artery. Furthermore diltiazem seems not to interact with histamine receptors in both vascular tissues.
- 公益社団法人日本薬学会の論文
著者
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Takayanagi I
Toho Univ. School Of Pharmaceutical Sciences Chiba Jpn
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Ohashi M
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Ohashi Mitsuo
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Iwata Takeshi
Department Of Architecture Faculty Of Engineering Mie University
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Iwata Takeshi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Ohashi M
Tanabe Seiyaku Co. Ltd. Saitama Jpn
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KUMAGAI NAOMI
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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KUNOU EIKO
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Kunou Eiko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Kumagai Naomi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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