A difference in alpha-adrenoceptor mechanisms in vasa deferential isolated from young and old rats.
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概要
- 論文の詳細を見る
A difference in alpha-adrenoceptor mechanisms in vasa deferentia isolated from 3 weeks old and 40 weeks old rats were studied by analysis of the concentration-response curve of norepinephrine and Scatchard plot of specific [<SUP>3</SUP>H]-prazosin binding to microsomal fractions. The efficacy of norepinephrine and capacity of the maximum binding sites of[<SUP>3</SUP>H]-prazosin estimated in 40 weeks old rats were larger than those in the 3 weeks old rats, while there was no difference in the affinity of norepinephrine estimated in the 3 weeks old rats and in the 40 weeks old rats. The increase of efficacy for norepinephrine in the vas deferens from the 40 weeks old rats is due to the increase in the total concentration of alphaadrenoceptors.
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Maeda Osamu
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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ISHIZUKA Masami
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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