Characteristics of Ca^<2+> Oscillations in Ileal Longitudinal Muscle Cells of Guinea Pig
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概要
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We studied the mechanisms and characteristics of the spontaneously evoked intracellular Ca2+ changes(Ca2+ oscillations)in ileal longitudinal smooth muscle from guinea pig.Two-dimensional images of Ca2+ oscillations were obtained at 33-ms intervals with a Ca2+-sensitive fluorescence probe, fluo-3 using the intensified CCD camera.Nicardipine(10-7M)significantly decreased the maximum level of fluorescence intensity of the Ca2+ oscillations, inhibited the frequency of the oscillations and tended to decrease the basal level of fluorescence intensity.However, tetrodotoxin(3×10-7M)did not affect these oscillations.Phorbol 12, 13-dibutyrate(10-7M)significantly increased the maximum level of fluorescence intensity and the frequency of Ca2+ oscillations, and it changed them to steady and chronometric Ca2+ oscillations.Cyclopiazonic acid(3×10-5M)also significantly increased the frequency of Ca2+ oscillations.Acetylcholine(10-8M)increased the basal and maximum level of fluorescence intensity and the frequency of Ca2+ oscillations, and accelerated their onset.The increase of basal level of fluorescence intensity was then decreased by cyclopiazonic acid treatment.These results suggest that the augmentation of Ca2+ oscillations is mainly due to the activation of L-type Ca2+ channels, which is modulated by protein kinase C, and that the emptying of intracellular Ca2+ stores may activate the Ca2+ oscillations mediated through the increase of Ca2+ influx in ileal smooth muscle of guinea pig.
- 社団法人 日本薬理学会の論文
- 2000-04-01
著者
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SATOH Mitsutoshi
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Koike Katsuo
東京薬科大学 内分泌分子薬理学
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Koike K
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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KOIKE Katsuo
Toho University School of Pharmaceutical Sciences
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Koike K
Toho Univ. Chiba Jpn
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Satoh Mitsutoshi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Takayanagi I
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Satoh Mitsutoshi
東邦大学 薬学部薬物安全性学
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