Evidence for release of prostaglandin F2.ALPHA. in contractile response of guinea pig trachea to norepinephrine.
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概要
- 論文の詳細を見る
The concentration (10<SUP>-8</SUP>-10<SUP>-5</SUP> M)-;dependent contractile response of norepinephrine was completely inhibited by cyclooxygenase inhibitors but not by a thromboxane synthetase inhibitor. The amount of prostaglandin F<SUB>2α</SUB> was significantly increased in the presence of norepinephrine (10<SUP>-5</SUP>M). Norepinephrine increased the amount of prostaglandin D<SUB>2</SUB>, although not significantly. The norepinephrine-evoked prostaglandin release was inhibited by tolazoline (3×10<SUP>-5</SUP> M). These results suggest that norepinephrine evoked the release of prostaglandins, mainly prostaglandin F<SUB>2α</SUB> to induce the contraction of the guinea pig trachea.
- 公益社団法人 日本薬理学会の論文
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
-
Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
-
Kawano Ken-ichi
Department Of Orthopaedic Surgery Graduate School Of Medicine University Of Tokyo
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