Effects of aging on α_1-adrenoceptor mechanisms in the isolated mouse aortic preparation
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概要
- 論文の詳細を見る
The effects of aging on α_1-adrenoceptor (α_1-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol. The potency of noradrenaline, estimated as its pD_2 value, increased with age from 5- to 10-weeks, but decreased thereafter with age from 10- to 40-weeks. However, the affinity of prazosin (pA_2 value) did not change with aging. These results suggest that age-related change in noradrenaline potency is not attributable to the change of drug affinity to α_1-ARs, but is possibly due to drug affinity-unrelated factors such as change of the reserve of α_1-ARs.
- 日本平滑筋学会の論文
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Michikawa Hiromi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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FUNABIKI Midori
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Funabiki Midori
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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