Argininosuccinate Synthetase Activity in Parotid Glands
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概要
- 論文の詳細を見る
In nitric oxide (NO)-generating cells, the citrulline/NO cycle is an important pathway in controlling the arginine supply because NO is generated from arginine by the activation of NO synthase. Argininosuccinate synthetase (AS ; EC 6.3.4.5) is a rate-limiting enzyme in the citrulline/NO cycle, which catalyses the condensation of citrulline and aspartate to form argininosuccinate, the immediate precursor of arginine. In this report, we examined AS activity in the parotid glands of rat, rabbit, mouse, and guinea pig. AS activity was detected in all species, and, in the rabbit parotid gland, most of the activity was observed in the cytosolic fraction. In the parotid glands of postnatal rabbits, AS activity increased prior to NOS activity. These results suggest that AS contributes to NO generation in the parotid gland.
- 日本大学松戸歯学部 口腔科学研究所の論文
著者
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Shibutani Koh
Department Of Anesthesiology Nihon University School Of Dentistry At Matsudo
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Sugiya Hiroshi
Department Of Physiology And Research Institute Of Oral Science Nihon University School Of Dentistry
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Furuyama Shunsuke
Department Of Physiology And Research Institute Of Oral Science Nihon University School Of Dentistry
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Michikawa Hiromi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Furuyama Shunsuke
Departments of Physiology, Nihon University School of Dentistry at Matsudo
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Sairennji Nakayasu
Departments of Anesthesiology, Nihon University School of Dentistry at Matsudo
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Kohgo Hirohito
Departments of Anesthesiology, Nihon University School of Dentistry at Matsudo
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Michikawa Hiromi
Departments of Physiology, Nihon University School of Dentistry at Matsudo
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Sugiya Hiroshi
Departments of Physiology, Nihon University School of Dentistry at Matsudo
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