The β_2- and β_3-Adrenoceptor-Mediated Relaxation Induced by Fenoterol in Guinea Pig Taenia Caecum
スポンサーリンク
概要
- 論文の詳細を見る
Fenoterol, a β_2-adrenoceptor selective agonist, belongs to the arylethanolamine class. To understand the receptor subtypes responsible for β-adrenoceptor-mediated relaxation of guinea pig taenia caecum, we investigated the effect of fenoterol. Fenoterol caused concentration-dependent relaxation of the guinea pig taenia caecum. Propranolol, bupranolol and butoxamine produced shifts of the concentration-response curve for fenoterol. Schild regression analyses carried out for propranolol, butoxamine and bupranolol against fenoterol gave pA_2 values of 8.41, 6.33 and 8.44, respectively. However, in the presence of 3×10^-4 M atenolol, 10^-4 M butoxamine and 10^-6 M phentolamine to block the β_1-, β_2- and α-adrenoceptor effects, respectively, Schild regression analysis carried out for bupranolol against fenoterol gave pA_2 values of 5.80. These results suggest that the relaxant response to fenoterol in the guinea pig taenia caecum is mediated by both the β_2- and the β_3-adrenoceptors.
- 日本平滑筋学会の論文
著者
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Koike Katsuo
東京薬科大学 内分泌分子薬理学
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Koike K
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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KOIKE Katsuo
Toho University School of Pharmaceutical Sciences
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Koike K
Toho Univ. Chiba Jpn
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Horinouchi Takahiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Horinouchi T
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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AKIMOTO Yurie
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Akimoto Yurie
Department Fo Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Horinouchi Takahiro
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Horinouchi Takahiro
Department Of Cellular Pharmacology Graduate School Of Medicine Hokkaido University
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