Comparison of the Inhibitory Effects of Docosahexaenoic Acid (DHA) on U46619-and Phenylephrine-Induced Contractions in Guinea-Pig Aorta(Pharmacology)

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概要

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• Inhibitory effects of docosahexaenoic acid (DHA) on the muscle contractions induced by U46619, a thromboxane A_2 (TXA_2) mimetic, and phenylephrine were compared in guinea-pig aorta. In de-endothelialized guinea-pig aortic ring preparations, DHA at 10μM strongly inhibited a sustained contraction produced by U46619 (3-100nM) whereas it did not exhibit an appreciable effect on phenylephrine (3-10μM)-induced contraction. The present findings indicate that DHA inhibits more selectively TXA_2 receptor (TP receptor)-mediated vascular contraction than α-adrenoceptor-mediated response. Selective inhibition by DHA of TP receptor-mediated contraction of blood vessels seems underlie in part the mechanisms by which this polyunsaturated fatty acid exerts its circulatory-protective effects.

• 公益社団法人日本薬学会の論文
• 2005-07-01

著者

• KOIKE Katsuo

  Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

• TANAKA Hikaru

  Department of Pharmacology, Toho University School of

• SHIGENOBU Koki

  Department of Pharmacology, Toho University School of

• Koike Katsuo

  東京薬科大学 内分泌分子薬理学

• Koike K

  Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn

• Koike Katsuo

  Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences

• Tanaka Hikaru

  Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn

• Tanaka H

  Department Of Pharmacology Toho University School Of Pharmaceutical Sciences

• Shigenobu K

  Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences

• Shigenobu K

  Department Of Pharmacology Toho University School Of Pharmaceutical Sciences

• Shigenobu Koki

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Tanaka Yoshio

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

• Tanaka Hikaru

  Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.

• Tanaka Hikaru

  Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences

• Shigenobu Koki

  Toho University School Of Pharmaceutical Sciences

• KOIKE Katsuo

  Toho University School of Pharmaceutical Sciences

• Koike K

  Toho Univ. Chiba Jpn

• Tanaka Yoshio

  Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.

• Toyoda Yoshihiro

  Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.

• Tanaka Yoshio

  Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences

• OTSUKA Kazuoki

  Department of Pharmacology, Toho University School of Pharmaceutical Sciences

• Tanaka Hikaru

  Department Of Internal Medicine Sasebo Senjyu Hospital

• Otsuka Kazuoki

  Department Of Pharmacology Toho University School Of Pharmaceutical Sciences

• Tanaka Yoshio

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Tanaka Yoshio

  Department Of Applied Chemistry Faculty Of Engineering Yokohama National University

• Tanaka Hikaru

  Department Of Internal Medicine Hirosaki Municipal Hospital

• Tanaka Hikaru

  Department of Endocrinology and Metabolism, Hirosaki University

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