Pathophysiological Significance of T-type Ca^<2+> Channels : T-type Ca^<2+> Channels and Drug Development
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概要
- 論文の詳細を見る
T-type Ca2+ channels are present in cardiovascular, neuronal, and endocrine systems; and they are now receiving attention as novel therapeutic targets. Many drugs and compounds non-specificaly block T-type Ca2+ channels. Certain dihydropyridine compounds, such as efonidipine, have blocking activity on both L-type and T-type Ca2+ channels which possibly underlies their excellent clinical profiles such as minimum reflex tachycardia and renal protection. Selective inhibitors of T-type Ca2+ channels, such as non-hydrolyzable mibefradil and R(−)-efonidipine, are powerful pharmacological tools for further studies and may lead to the development of novel therapeutic strategies.
- 社団法人 日本薬理学会の論文
- 2005-11-20
著者
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Shigenobu Koki
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
関連論文
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