Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle
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概要
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The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized. In embryonic chick ventricles, carbachol (CCh) produced positive inotropy at micromolar concentrations. In hatched chick ventricles, CCh produced negative inotropy at nanomolar concentrations. Neither positive nor negative inotropy was observed in the 19 – 21-day-old embryos. Both positive and negative inotropy were also observed with acetylcholine and oxotremoline-M. The CCh-induced positive inotropy in 7 – 9-day-old embryonic ventricles and the negative inotropy in 1 – 3-day-old hatched chick ventricles were antagonized by muscarinic receptor antagonists; pA2 values for the positive and negative responses of pirenzepine were 7.5 and 7.2, those of AF-DX116 (11-[(2-[(diethylamino)methyl]-1-piperidinyl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepine-6-one) were 6.8 and 6.9, those of 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) were 9.0 and 8.5, and those of himbacine were 7.0 and 8.0, respectively. CCh had no effect on action potential configuration. In conclusion, the positive inotropy is most likely mediated by muscarinic M1 receptors and the negative inotropy is mostly likely mediated by muscarinic M4 receptors.
- 社団法人 日本薬理学会の論文
- 2007-01-20
著者
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Hirose Kunihiko
Department of Cardiology, Otsu Red Cross Hospital
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Nouchi Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimizu Nagako
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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KAERIYAMA Seri
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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MURAMATSU Akiko
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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SATO Masumi
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Hirose Kunihiko
Department Of Cardiology Otsu Red Cross Hospital
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Hirose Kunihiko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Sato Masumi
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Kaeriyama Seri
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Muramatsu Akiko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Muramatsu Akiko
Department Of Pediatrics Nagoya City University Medical School
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Sato Masumi
Department Of Bioscience Tokyo University Of Agriculture
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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