Involvement of Intracellular Ca^<2+> in the Regulatory Volume Decrease After Hyposmotic Swelling in MDCK Cells
スポンサーリンク
概要
- 論文の詳細を見る
We examined the source of Ca2+ involved in the volume regulation of Madin-Darby canine kidney (MDCK) cells with confocal microscopy and fluoroprobes. Hyposmosis induced a transient increase in cell volume, as well as cytoplasmic Ca2+, which peaked at 3 to 5 min and gradually decreased to reach the initial value within about 30 min. This late decrease in cell volume, as well as the transient rise in cytoplasmic Ca2+, was reduced in Ca2+-free solution and was abolished by pretreatment with thapsigargin. In conclusion, Ca2+ released from the intracellular store contributes to the regulatory volume decrease following hyposmotic swelling in MDCK cells.
- 社団法人 日本薬理学会の論文
- 2007-08-20
著者
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Iida-tanaka Naoko
Department Of Food Science Otsuma Women's University
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Iida Tanaka
Department Of Food Science Otsuma Women's University
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Nakamura Ryu
Advanced Imaging Microscopy Department Product Management Division Of Microscopy
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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TAMURA Miku
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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Tamura Miku
大妻女子大学 食物学科
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Tamura Miku
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Iida Tanaka
Department Of Food Science Faculty Of Home Economics Otsuma Woman's University
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Kaneko Megumi
Department Of Chemistry School Of Science Kitasato University
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Kaneko Megumi
Department Of Food Science Faculty Of Home Economics Otsuma Woman's University
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Iida-Tanaka Naoko
Department of Biochemistry, Teikyo University School of Medicine
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