Change in Annexin A3 Expression by Regulatory Factors of Hepatocyte Growth in Primary Cultured Rat Hepatocytes(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
We have recently reported that annexin (Anx) A3 expression is necessary for hepatocyte growth in cultured rat hepatocytes seeded at half the subconfluent density on collagen. In the present study, we investigated the effects of various regulatory factors of hepatocyte growth on AnxA3 expression. AnxA3 expression was significantly reduced in hepatocytes cultured under various growth inhibitory conditions such as presence of dexamethasone, culture at subconfluent cell density, and on EHS-Matrigel and lactose-carrying styrene polymer. On the other hand, hepatocyte growth factor and epidermal growth factor, stimulators of hepatocyte growth, significantly increased AnxA3 expression in hepatocytes cultured on EHS-Matrigel. These results show close correlation between known stimulatory or inhibitory actions of various factors to hepatocyte growth and increase or decrease in AnxA3 expression, and suggest the involvement of AnxA3 in their regulation of hepatocyte growth.
- 公益社団法人日本薬学会の論文
- 2006-07-01
著者
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Seki T
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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HYUGA Masashi
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences of Biologica
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Noma Seiji
The Japan Health Sciences Foundation
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Seki Taiichiro
Department of Agricultural Chemistry, College of Agriculture and Veterinary Medicine, Nihon Universi
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Ariga Toyohiko
Department of Agricultural Chemistry, College of Agriculture and Veterinary Medicine, Nihon Universi
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Hyuga Masashi
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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HARASHIMA Mizuho
Department of Nutrition and Physiology, Nihon University College of Bioresource Sciences
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NIIMI Shingo
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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Niimi S
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Seki Taiichiro
Lab. Of Nutrition And Physiology Dep. Of Chemistry And Life Sci. Nihon Univ. Coll. Of Bioresource Sc
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Seki T
Nihon Univ. Coll. Of Bioresource Sci. Fujisawa Jpn
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Seki Taiichiro
Department Of Agricultural And Biological Chemistry College Of Agriculture And Veterinary Medicine N
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Seki Taiichiro
Laboratory Of Nutrition And Physiology Department Of Agricultural And Biological Chemistry Nihon Uni
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Hayakawa Takao
Pharmaceutical Research and Technology Institute, Kinki University
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Hayakawa Takao
Div. Of Biological Chemistry And Biologicals National Inst. Of Health Sciences Jpn
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Hayakawa T
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Hayakawa T
National Institute Of Health Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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Ariga Toyohiko
Nihon Univ. Graduate School Of Applied Life Sciences
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Ariga Toyohiko
Department Of Agricultural And Biological Chemistry College Of Agriculture And Veterinary Medicine N
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Ariga Toyohiko
Department Of Agricultural And Biological Chemistry Nihon University College Of Bioresouce Sciences
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関 敏美
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Hayakawa Takao
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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KOYANAGI Hitomi
Department of Nutrition and Physiology, Nihon University College of Bioresource Sciences
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Kazama H
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Hyuga Masashi
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Niimi Shingo
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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