Annexin A3-Expressing Cellular Phenotypes Emerge from Necrotic Lesion in the Pericentral Area in 2-Acetylaminofluoren/Carbon Tetrachloride-Treated Rat Livers
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概要
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Recently we found a small hepatocyte-specific protein, annexin A3 (AnxA3), in fractionated adult rat hepatocytes. Here we describe the results of an in vivo demonstration of AnxA3-expressing cellular phenotypes in the liver with 2-acetylaminofluoren (2-AAF)/carbon tetrachloride (CCl4)-injury. In association with an elevation of alanine amino transferase (ALT) and aspartic acid amino transferase (AST) activities, hepatic AnxA3 mRNA increased markedly. AnxA3-positive cells were detected in clustered cells present in or emerging from the pericentral region. These albumin-expressed cells were histologically similar to cells expressing CD34, a hematopoietic cell marker protein. The number of clusters decreased in the days following CCl4 treatment, and annexin-negative, but albumin-positive, oval cells appeared. We concluded that the agent-induced liver defect initially recruits bone marrow-derived cells, and that it promotes differentiation of these cells into AnxA3-positive cells, followed by emergence of the oval cells, which might have a role in the restitution of the damaged liver.
- 社団法人 日本農芸化学会の論文
著者
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Ito Yoshimasa
Laboratory of Nutrition and Physiology, Department of Chemistry and Life Science, Nihon University C
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SEKI Taiichiro
Laboratory of Nutrition and Physiology, Department of Chemistry and Life Science, Nihon University C
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ARIGA Toyohiko
Laboratory of Nutrition and Physiology, Department of Chemistry and Life Science, Nihon University C
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Ito Yoshimasa
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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NIIMI Shingo
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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Watanabe Takenori
Laboratory of Nutrition and Physiology, Department of Agricultural and Biological Chemistry, Nihon U
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Nagatomo Shunsuke
Laboratory of Nutrition and Physiology, Department of Agricultural and Biological Chemistry, Nihon U
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Ito Yukihiko
Fancl Research Institute Fancl Corporation
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