Regulation of Inhibin β Chains and Follistatin mRNA Levels During Rat Hepatocyte Growth Induced by the Peroxisome Proliferator Di-n-butyl Phthalate
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概要
- 論文の詳細を見る
Peroxisome proliferators stimulate hepatocyte growth in rat liver in viva. Activin A, a homodimer of inhibin β_A, inhibits DNA synthesis in hepatocytes. The inhibitory action of activin A is suppressed by follistatin, an activin-binding protein. In this paper, we investigated whether administration of di-n-butyl phthalate (DBP), a peroxisome proliferator, modifies the production of activin A and follistatin in rat liver by hourly monitoring of inhibin β_A and follistatin mRNA levels by reverse transcriptase polymerase chain reaction analysis. The mRNA levels of the other inhibin β chains (inhibin β_B and β_C) were examined in a similar manner. The inhibin β_A mRNA level decreased to about 30% by 3 h after DBP administration (8.6 mmol/kg body weight), remained low until 12 h, and returned to its original level by 24 h. The follistatin mRNA level increased to about 2 times by 6 h, and returned to its original level by 24 h. The inhibin β_B mRNA had started to increase by 1 h, peaked at 6 h at about 4 times its initial level, and returned to its original level by 12 h. The inhibin β_C mRNA level had doubled by 6 h and it returned to its original level. These results indicate that the growth stimulatory action of peroxisome proliferators may be mediated via the decrease in activin A level and activity and suggest that the increases in follistatin as well as inhibin β_B and β_C chains may play a role in peroxisome proliferator-stimulated hepatocyte growth.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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FUKUOKA Masamichi
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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HAYAKAWA Takao
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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KOBAYASHI Tetsu
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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Fujii M
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Fujii Makiko
Department Of Pharmaceutics Showa College Of Pharmaceutical Science
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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NIIMI Shingo
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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Niimi S
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Hayakawa Takao
Div. Of Biological Chemistry And Biologicals National Inst. Of Health Sciences Jpn
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Hayakawa T
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Hayakawa T
National Institute Of Health Sciences
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Hayakawa Takao
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kobayashi Tetsu
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Kawanishi Toru
国立医薬品食品衛生研究所
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Fukuoka Masamichi
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Fukuoka M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Niimi Shingo
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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