Unkeito, a traditional Kampo formula, exhibits a selective estrogen receptor modulator-like activity : Prevention of osteoporosis in ovariectomized mice

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概要

• 論文の詳細を見る

• 温経湯は月経異常や更年期障害などの症状に対する漢方処方の一つである。我々は温経湯が卵巣摘出マウス海綿骨密度と子宮に及ぼす影響について検討した。その結果,温経湯が選択的エストロゲン受容体モジュレーター様作用を示したので報告する。10週齢Balb/c雌マウスを両側卵巣摘出し2週間飼育した。水投与群(OVX),エストロゲン投与群,温経湯投与群,エストロゲン+温経湯投与群に分けて2週間経口投与を行い,大腿骨海綿骨骨密度・子宮湿重量・子宮内膜厚をそれぞれ測定した。OVXの海綿骨骨密度,子宮湿重量および子宮内膜厚は偽手術群と比べ有意に低下していた。温経湯投与群の海綿骨骨密度はOVXと比べ有意に増加していた。温経湯投与群の子宮湿重量および子宮内膜厚はOVXと有意差はなかった。さらにエストロゲンによって増加した子宮湿重量および子宮内膜厚は温経湯投与によって低下した。これらの結果から卵巣摘出マウスに温経湯をわずか2週間投与することで,子宮湿重量および子宮内膜厚の増加を伴わずに,エストロゲン減少による海綿骨密度の低下を防ぐことが可能なことを示した。

• 2009-02-28

著者

• 日向 須美子

  北里大学 東洋医学総合研究所 臨床研究部

• 日向 須美子

  北里大学東洋医学総合研究所臨床研究部

• OIKAWA Tetsuro

  Department of Clinical Research, Oriental Medicine Research Center, Kitasato University

• Yamaguchi Teruhide

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• HYUGA Masashi

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences of Biologica

• Hyuga Masashi

  Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences

• Yamaguchi Teruhide

  Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences

• 日向 須美子

  東京工業大学生命理工学部

• WATANABE Koji

  Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine

• SEKIGUCHI Atsuko

  Department of Clinical Research, Oriental Medicine Research Center, Kitasato University

• ENDO Mari

  Department of Clinical Research, Oriental Medicine Research Center, Kitasato University

• TSUDA Tokutaro

  Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine

• HANAWA Toshihiko

  Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine

• Endo Mari

  Department Of Clinical Research Oriental Medicine Research Center Kitasato University

• Tsuda Tokutaro

  Kitasato University Graduate School Doctoral Program Of Medical Science Oriental Medicine:department

• Sekiguchi Atsuko

  Department Of Clinical Research Oriental Medicine Research Center Kitasato University

• Oikawa Tetsuro

  Department Of Clinical Research Oriental Medicine Research Center Kitasato University

• Hanawa T

  Kitasato Univ. Graduate School Kanagawa Jpn

• Hanawa Toshihiko

  Kitasato Inst. Tokyo Jpn

• Tsuda Tokutaro

  Kitasato Univ. Graduate School Kanagawa Jpn

• Watanabe Koji

  Kitasato University Graduate School Doctoral Program Of Medical Science Oriental Medicine:department

• Watanabe Koji

  Kitasato Univ. Graduate School Kanagawa Jpn

• Hyuga Masashi

  National Inst. Health Sci. Tokyo Jpn

• Yamaguchi Teruhide

  Division of Biological Chemistry & Biologicals, National Institute of Health Sciences

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