Differentiation between Hangekobokuto and Kososan based on pupillary dynamics : Evaluation of autonomic nerve function

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概要

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• 半夏厚朴湯および香蘇散は,神経症・うつ状態をともなう気鬱に使用される自律神経疾患の代表処方であるが,両処方の使用目標は重複する部分が多く,鑑別が容易ではない。我々は,漢方薬の治療効果と自律神経との関係を明らかにすることを目的に浜松ホトニクス社製の赤外線電子瞳孔計Iriscorder^[○!R] C-7364(以下,Iriscorder^[○!R])を用いて検討してきた。瞳孔反応における自律神経機能の観点より半夏厚朴湯および香蘇散の客観的な鑑別が可能であるか検討した。その結果,半夏厚朴湯は交感神経が亢進している症例の交感神経活動を抑制し,香蘇散は副交感神経が亢進している症例の交感神経活動を促進する作用があることが示唆された。漢方薬が自律神経系に調節的に働く様子を客観的に証明することができたことより,Iriscorder^[○!R]を用いた評価方法は漢方薬の効果判定法に適していると思われた。

• 和漢医薬学会の論文
• 2006-10-20

著者

• 若杉 安希乃

  北里大学大学院医療系研究科

• 若杉 安希乃

  北里研究所東洋医学総合研究所臨床試験管理室

• HOSHINO Takayuki

  Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology

• HANAWA Toshihiko

  Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute

• Ito Hidenori

  Department Of Molecular Neurobiology Institute For Developmental Research Aichi Human Service Center

• Ito Hidenori

  Kitasato Univ. Tokyo Jpn

• Ito Hidenori

  Department Of Biochemistry Institute For Developmental Research Aichi Human Service Center

• WATANABE Koji

  Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute

• Hoshino Takayuki

  Kitasato Univ. Tokyo Jpn

• ODAGUCHI Hiroshi

  Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate S

• SHODA Hisakazu

  Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate S

• GAMO Yuji

  Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate S

• Watanabe Koji

  Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital

• Gamo Yuji

  Department Of Clinical Research Oriental Medicine Research Center Kitasato University:department Of

• Shoda Hisakazu

  Department Of Oriental Medicine Doctoral Program Of Medical Science Kitasato University Graduate Sch

• Odaguchi Hiroshi

  北里大学 大学院医療系研究科東洋医学

• Odaguchi Hiroshi

  Department Of Oriental Medicine Doctoral Program Of Medical Science Kitasato University Graduate Sch

• Gamo Yuji

  Dep. Of Clinical Res. Oriental Medicine Res. Center Kitasato Univ.

• Hanawa Toshihiko

  Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute : Kitasato

• Hanawa Toshihiko

  Department Of Oriental Medicine Doctoral Program Of Medical Science Kitasato University Graduate Sch

• Watanabe Koji

  Kitasato University Graduate School Doctoral Program Of Medical Science Oriental Medicine:department

• Ito Hidenori

  Department Of Bioapplied Chemistry Osaka City University

• Watanabe Koji

  Department Of Cardiology Hashima City Hospital

• Hanawa Toshihiko

  Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute

• Hoshino Takayuki

  Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Japan

• HOSHINO Takayuki

  Department of Agricultural Chemistry, The University of Tokyo

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