Cell-Driven Three-Dimensional Manipulation of Microparts for a Microassembly
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概要
- 論文の詳細を見る
Biological motility consisting of cell migration can be embedded in nano- and micro-mechanical systems. We have focused on the actin polymerization to employ its generative force as the driving force of a nano mechanical system. Cells are a self-sustaining full system which contains an energy supply and has self-organization of actin filaments. This self-organized driving force powered by the cells should be utilizable in a functionally designed nano or micro mechanical assembly. This paper describes locomotion of micro-parts driven by cell migration. A method to generate three-dimensional (3D) cell-driven operation of the micro-parts was investigated for a micro-assembly using two-dimensional (2D) cell-adhesive patterning of a substrate. Cyclic reattachment of cell membranes occurred on a discrete cell-adhesive portion within a 100-μm-pitch checkerboard pattern during cell migration. These movements of cells modulated the 2D cell migration to a 3D tilting movement of the micro-parts-on-cells and 180-μm-length micro-parts were successfully flipped by the cell migration power.
- 2010-06-25
著者
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HOSHINO Takayuki
Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology
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Konno Tomohiro
Department Of Materials Engineering And Bioengineering School Of Engineering University Of Tokyo
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Tomohiro Konno
Department of Bioengineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan
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Higashi Ayako
Department of Bio-Application and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
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Kazuhiko Ishihara
Department of Materials Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan
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Keisuke Morishima
Department of Bio-Application and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
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Keisuke Morishima
Department of Bio Applications and System Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
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HOSHINO Takayuki
Department of Agricultural Chemistry, The University of Tokyo
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