CHANGES IN HEMODYNAMICS WITH ADVANCING AGE IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS

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概要

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• The changes of hemodynamics were measured in spontaneously hypertensive rats (SHR) of increasing ages. Male SHR and Wistar rats of the Kyoto strain (WKY) at 4, 12, 24 and 48 weeks of age were used. The right jugular vein and the left femoral artery were cannulated and a thermister was placed in the ascending aorta. After 24-hour rest, heart rate (HR), mean arterial pressure (MAP) and cardiac output (CO) were measured .The ratio of left ventricular weight (LVMI) of 4 week-old SHR had already increased significantly when compared to WKY. The HR in 4-week-old SHR was significantly higher than WKY. The increased HR in young SHR indicates the hypersensitivity of the sympathetic nervous system. Increased CO in 4 week-old SHR was due to high HR. The ratio of heart work to left ventricular mass (HW/LVM) of SHR at all age groups was not different from that of WKY, although the ratio of heart work to body weight (HWI) had a tendency to rise in SHR as compared to that in WKY. Our conclusion is that the development of LVM adapts to HW.

• 社団法人日本循環器学会の論文
• 1985-04-20

著者

• Yamori Y

  Institute For World Health Development Mukogawa Women's University

• Yamori Yukio

  福山大学 衛生化学

• Yamori Yukio

  Department Of Pathology Faculty Of Medicine Kyoto University

• NISHIO TOSHIKAZU

  Department of Pediatrics, Kobe Central Municipal Hospital

• Yamori Y

  Departments Of Pathology Shimane Medical University

• Yamori Yukio

  Who Collaborating Center

• Kihara Masahiro

  Department of Pathology, Shimane Medical University

• WATANABE Koji

  Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute

• Watanabe Koji

  岐阜県立岐阜病院

• Watanabe Koji

  Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital

• MORI Chuzo

  Department of Clinical Psychology, Kyoto-Bunkyo Junior College

• Nishio Toshikazu

  Department Of Pediatrics Shimane Medical University

• Yamori Yukio

  Departments Of Pathology Shimane Medical University

• Mori Chuzo

  Department Of Clinical Psychology Kyoto-bunkyo Junior College

• KIHARA Masahiro

  Kyoto University School of Public Health

• Nishio Toshikazu

  Department Of Pediatrics Kobe Central Municipal Hospital

• Kawado M

  Department Of Hygiene Fujita Health University School Of Medicine

• Kihara M

  Department Of Preventive Medicine And Public Health Keio University School Of Medicine

• Kihara Masahiro

  Department Of Global Health And Socio-epidemiology Kyoto University School Of Public Health

• Kihara Masahiro

  Research Institute For Theoretical Physics Hiroshima University

• Kato Masahiro

  Department Of Neurology Suzuka National Hospital

• Mori Chuzo

  Dept. Of Pediat. Kyoto Univ.

• Watanabe Kohji

  Department Of Pediatrics Shimane Medical University

• Watanabe Kohji

  Department Of Pediatrics Shimane Medical School

• Watanabe Koji

  Department Of Cardiology Hashima City Hospital

• Mori Chuzo

  Department Of Pediatrics Kyoto University Faculty Of Medicine.

• KIHARA Masahiro

  Research Institute for Theorerical Physics, Hiroshima University

• Yamori Yukio

  Department of Life Science, Graduate School of Human and Environmental, Kyoto University

• Kihara Masahiro

  Department of Epidemiology, Kanagawa Cancer Center Research Institute

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