Pharmacodynamic Studies on the Cardiovascular System of Spontaneously Hypertensive Rats

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概要

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• The cardiovascular responses to pressor, de-pressor agents and carotid occlusion in the Spontaneously Hypertensive Rats (OKAMOTO and AOKI) were investigated. Spontaneously hypertensive rats were divided into 3 groups, i. e., the pre-hypertensive or transitional stage (Sy ; 40-60 days old), the earliest hypertensive stage (Sp ; 60-110 days old) and the early hypertensive stage (Sa; 130-210 days old), and were compared with acute and chronic renal infarction hypertension (Ry, Ra), acute constricted renal artery hypertension (Rg) and normotensive controls at the corresponding age, respectively. Direct blood pressure was recorded manometrically on kymograph under chloralose (40 mg/kg, intravenous administration) anesthesia and all pressor or depressor agents were administered intravenously and the following results were obtained. 1) Spontaneously hypertensive rats (Sp, Sa) after the development of hypertension, which seemed somewhat easily depressed by general anesthesia maintained hypertensive blood pressure level under chloralose (40mg/ kg) anesthesia. 2) Response to adrenalin (5γ/kg) was slightly decreased in spontaneously hypertensive rats (Sy, Sa), but response to noradrenalin (5γ/kg) showed an increasing tendency in spontaneously hypertensive rats in the early stage (Sa) as well as in chronic renal hypertensive rats (Ra). 3) Pressor response induced by bilateral carotid occlusion for 20 seconds was significantly increased in spontaneously hypertensive rats (Sy, Sa) and renal hypertensive rats (Ry, Ra) in comparison with normotensive controls. Spontaneously hypertensive rats in the pre-hypertensive or transitional stage (Sy) did not show a significantly increased carotid occlusion reflex until atropine (2mg/kg) was administered. 4) The depressor effect of regitine (0.6mg/kg) in spontaneously hypertensive rats in the pre-hypertensive stage (Sy) was almost the same as that in controls. Spontaneously hypertensive rats in the early stage (Sa) showed nearly the same increased response as chronic renal hypertensive rats (Ra) but a significantly increased response in comparison with acute renal hypertensive rats (Ry). 5) The stable pressure level after hexamethonium (20mg/kg) administration was significantly lower in spontaneously hypertensive rats in the earliest hypertensive stage (Sp) than in acute renal hypertensive rats with constricted renal arteries (Rg). 6) The effect of acetylcholine (2γ/kg) on blood pressure was significantly increased in spontaneously hypertensive rats in the pre-hypertensive or transitional stage (Sy) and in acute renal hypertensive rats (Ry) as compared with controls. 7) These results suggested the probable participation of neural fractors in the development of spontaneous hypertension. Differences between spontaneous and renal hypertension as well as the similarity of spontaneous hypertension to human essential hypertension in early stage were also discussed.

• 社団法人日本循環器学会の論文
• 1966-08-15

著者

• SUZUKI Yasuhiro

  Department of Information Processing, Tokyo Institute of Technology

• Yamori Yukio

  Department Of Pathology Faculty Of Medicine Kyoto University

• MATSUMOTO MASAO

  Department of Palhology, Faculty of Medicine, Kyoto University

• OKAMOTO KOZO

  Department of Palhology, Faculty of Medicine, Kyoto University

• TAKEDA TOSHIO

  Dept. of Pathology, Facul. of Med., Kyoto University

• TABEI RYO

  Dept. of Pathology, Facul. of Med., Kyoto University

• TABEI RYO

  Department of Pathology, Faculty of Medicine, Kyoto University

• NOSAKA SHOICHIRO

  Department of Pathology, Faculty of Medicine, Kyoto University

• FUKUSHSIMA MASAKAZU

  Department of Pathology, Faculty of Medicine, Kyoto University

• HAZAMA Fumitada

  Department of Pathology, Faculty of Medicine, Kyoto University

• TAKEDA Toshio

  Department of Pathology, Faculty of Medicine, Kyoto University

• FUKUSHIMA Msakazu

  Department of Pathology, Faculty of Medicine, Kyoto University

• HAEBARA Hideyuki

  Department of Pathology, Faculty of Medicine, Kyoto University

• ICHIJIMA Kunio

  Department of Pathology, Faculty of Medicine, Kyoto University

• Suzuki Yasuhiro

  Central Research Laboratories Sankyo Co. Ltd.

• Fukushima Masakazu

  Dept. Of Pathology Facul. Of Med. Kyoto University

• Matsumoto Masao

  Department Of Palhology Faculty Of Medicine Kyoto University

• Haebara Hideyuki

  Department Of Pathology Teikyo University School Of Medicine

• Ichijima Kunio

  Department Of Pathology Faculty Of Medicine Kyoto University:(present)department Of Clinical Patholo

• Okamoto Kozo

  Dept. Of Pathology Facul. Of Med. Kyoto University

• Okamoto Kozo

  Department Of Pathology Kyoto University School Of Medicine

• Okamoto Kozo

  The Department Of Pathology Kyoto University School Of Medicine

• Yamori Yukio

  The Department Of Pathology Faculty Of Medicine Kyoto University

• Fukushsima Masakazu

  Department Of Pathology Faculty Of Medicine Kyoto University

• Okamoto Kozo

  Department Of Palhology Faculty Of Medicine Kyoto University

• Tabei Ryo

  The Department Of Pathology Faculty Of Medicine Kyoto University

• Tabei Ryo

  Dept. Of Pathology Facul. Of Med. Kyoto University

• Tabei Ryo

  Department Of Pathology Faculty Of Medicine Kyoto University

• Takeda Toshio

  Dept. Of Pathology Facul. Of Med. Kyoto University

• Takeda Toshio

  Department Of Electronics Fukuoka Campus Of Tokai University

• OKAMOTO K.

  Department of Polymer Science and Engineering, Kyoto Institute of Technology

• Hazama Fumitada

  Dept. Of Pathology Facul. Of Med. Kyoto University

• Hazama Fumitada

  Department Of Pathology Kyoto University Faculty Of Medicine:max-planck Institut Fur Psychiatrie:(pr

• Okamoto Kozo

  The Department Of Pathology Faculiy Of Medicine Kyoto University

• Suzuki Yasuhiro

  Department Of Breast And Endocrine Surgery Tokai University School Of Medicine

• Nosaka Syoichiro

  The Department Of Pathology Faculty Of Medicine Kyoto University

• Nosaka Shoichiro

  Deparment Of Physiology Mie University School Of Medicine

• Matsumoto Masao

  Department Of Medical Engineering Osaka University Graduate School Of Medicine

• Okamoto K.

  Department of Pathology, Faculty of Medicine, Kyoto University

• Yamori Yukio

  Department of Life Science, Graduate School of Human and Environmental, Kyoto University

• Hazama Fumitada

  Deparment of Pathology, Shiga University of Medical Science, School of Medicine

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