Autografting with peripheral blood CD34-positive cells following high-dose chemotherapy against breast cancer

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概要

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• We report autologous CD34^+ cell transplantation performed in 3 cases of recurrent breast cancer. The hematological recovery in these cases was assessed by comparing with that in the previous cases of autologous hematopoietic stem cell transplantation performed with the same high-dose chemotherapy regimen. Patient 1 was a 32-year-old woman with pulmonary and skeletal metastases; patient 2, a 55-year-old woman with pulmonary metastases; and patient 3, a 48-year-old woman with hepatic metastases. On day 1, cyclophosphamide 1000mg/m^2 and epirubicin 130mg/m^2 were administered concurrently with granulocyte colony-stimulating factor, and peripheral blood stem cells were harvested on days 14-16. These stem cells were processed using anti-CD34 monoclonal antibody and an immunomagnetic bead device, Isolex 300i^<TM>. The high-dose chemotherapy regimen consisted of cyclophosphamide 2000mg/m^2/day, div, and thiotepa 200mg/m^2/day, div on day -5, -4, and -3. The harvested CD34^+ cells numbered 3.9±2.8×10^6/kg (range: 0.73-7.8/10^6/kg), and the CFU-GM, 8.3±5.6×10^5/kg (range: 1.2-15.1/10^5/kg). After the separation, the percent of CD34^+ cells was 81.9±11.6% (range: 65.8-96.4%), the CD34^+ cell yield, 71.8±30.2% (range: 46.0-129.6%), and the CFU-GM yield, 48.9±9.1% (range: 35.3-62.0%). At the time of transplantation, the number of nucleated cells was 0.55±0.31×10^5/kg, and that of CFU-GM, 31.2±17.8×10^5/kg. Comparison of the hematological recovery in these three cases with that in patients receiving an identical high-dose chemotherapy regimen revealed recovery rates significantly faster than in patients having bone marrow transplants, and approximately identical with that in peripheral blood stem cell transplantation cases. Abbreviations: CD34^+, CD34-positive; AHSCT, autologous hematopoietic stem cell transplantation; G-CSF, granulocyte colony-stimulating factor; PBSC, peripheral blood stem cells; HDC, high-dose chemotherapy

• 東海大学の論文

著者

• HOTTA Tomomitsu

  Department of Hematology and Oncology, Tokai University School of Medicine

• Hotta Tomomitsu

  国立がんセンター中央病院 血液内科

• SUZUKI Yasuhiro

  Department of Information Processing, Tokyo Institute of Technology

• MAKUUCHI HIROYASU

  Department of Cardiovascular Surgery, Tokai University Hospital

• Tokuda Y

  Department Of Surgery Tokai University School Of Medicine

• Hotta T

  National Hospital Organization Nagoya Medical Center

• Hata Tomoko

  Nagasaki University

• Hata Tomoko

  Department Of Hematology Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki University G

• Tanaka Y

  Department Of Surgery Tokai University School Of Medicine

• Suzuki Yutaka

  Tokai University School Of Medicine Department Of Radiology

• Suzuki Yasuhiro

  Department Of Surgery Tokai University School Of Medicine

• Saito Yuki

  Department Of Surgery Tokai University School Of Medicine

• Saito Yuki

  Department Of Behavioral Science Tohoku University Graduate School Of Medicine

• Tajima Tomoo

  Department Of Surgety Tokai University School Of Medicine

• Tajima Tomoo

  Department Of 2nd Surgery School Of Medicine Tokai University

• Tajima Tomoo

  Department Of Surgery Tokai University School Of Medicine

• Tokuda Y

  Aichi Inst. Technol. Toyota Jpn

• Tokuda Yutaka

  Depertment Of Electronics Aichi Institute Of Technology

• Tokuda Yutaka

  Department Of Surgery Tokai University School Of Medicine

• Ohta M

  Department Of Surgery Tokai University School Of Medicine

• Ohta Masatoshi

  Department Of Surgery Tokai University

• Ohta Masatoshi

  Department Of Surgery School Of Medicine Tokai University

• KUBOTA Mitsuhiro

  Department of General Surgery, School of Medicine, Tokai University

• Hotta Tomomitsu

  Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi

• Hotta T

  Tokai Univ. School Of Medicine Kanagawa

• Sugio Yoshinori

  Department Of Surgery Tokai University School Of Medicine

• OKUMURA Akira

  Department of Surgery, Tokai University School of Medicine

• KUGE Soichi

  Department of Surgery Tokai University School of Medicine

• NAKAMURA Yoshihiko

  Department of Cell Transplantation Center, Tokai University School of Medicine

• Tanaka Yasuhiko

  Department Of Ophthalmology School Of Medicine Keio University

• Kuge S

  Department Of Surgery Tokai University School Of Medicine

• Makuuchi Hiroyasu

  Department Of Cardiovascular Surgery Tokai University Hospital

• Suzuki Y

  Department Of Surgery Tokai University School Of Medicine

• Saito Yuuki

  Department Of Surgery Tokai University School Of Medicine

• Kuge Soichi

  Department Of Immunology Tokai University School Of Medicine

• Okumura A

  Department Of Surgery Tokai University School Of Medicine

• Okumura Akira

  Department Of Radiology Kurashiki Central Hospital

• Tokuda Yutaka

  Department Of Breast And Endocrine Surgery Tokai University School Of Medicine

• Suzuki Yasuhiro

  Department Of Breast And Endocrine Surgery Tokai University School Of Medicine

• Kubota Mitsuhiro

  Department Of Surgery Tokai University School Of Medicine

• Kubota Mitsuhiro

  Department Of Surgery Tokai University Oiso Hospital

• Kubota Mitsuhiro

  Department Of Energy Engineering And Science Nagoya University

• Maruyama H

  Department Of Surgery Tokai University School Of Medicine

• Hotta Tomomitsu

  Nagoya Medical Center Nagoya Jpn

• Ohta Masatoshi

  Department Of Material Science And Technology Faculty Of Engineering Niigata University

• Hotta Tomomitsu

  Department Of Hematology Nagasaki University Hospital

• Nakamura Yoshihiko

  Department Of Cell Transplantation Center Tokai University School Of Medicine

• Kubota Mitsuhiro

  Department of Energy Engineering & Science, Nagoya University

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