Clinicopathological correlation between expression of PTHrP receptor and various prognostic factors in breast cancer without axillary lymph node metastasis
スポンサーリンク
概要
- 論文の詳細を見る
Purpose; Expression of PTHrP is immunohistologically found in mammary tissues of all the normal cell, hyperplasia and malignant cell. In patients of breast cancer, positive ratio of PTHrP is reportedly 60-69%. Higher positive ratios of PTHrP are found in breast cancer showing bone metastasis than those without bone metastasis. And, breast cancer patients with PTHrP positive show poor prognosis suggesting a relationship to histological grade. Regarding PTHrP receptor, there is few report on its physiological role and relationship to other prognostic factors. The aim of this study was to determine the correlation between PTHrP receptor and various prognostic parameters of breast cancer patients with no axillary node metastasis. Material and methods; We employed 26 breast cancer patients, who showed negative axillary node metastasis and did not receive postoperative therapy. We examined relationship between PTHrP receptor and various prognostic factors such as hormone receptors, MIB-1 index, proliferation of cell nuclear antigen (PCNA), DNA ploidy, S-phase fraction, age, tumor diameter, c-erbB-2, and Cathepsin D. Results; No relationship between expression of PTHrP receptor and the cancer recurrence. PTHrP receptor correlated MIB-1 index alone (p<0.044). Conclusions; This findings suggest PTHrP receptor is related to the tumor proliferation of breast cancer.
- 東海大学の論文
著者
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Osamura Robert
Department of Pathology, Tokai University School of Medicine
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Umemura Shinobu
Department of Pathology, Tokai University School of Medicine
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SUZUKI Yasuhiro
Department of Information Processing, Tokyo Institute of Technology
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Tokuda Y
Department Of Surgery Tokai University School Of Medicine
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Tanaka Y
Department Of Surgery Tokai University School Of Medicine
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Suzuki Yutaka
Tokai University School Of Medicine Department Of Radiology
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Suzuki Yasuhiro
Department Of Surgery Tokai University School Of Medicine
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Saito Yuki
Department Of Surgery Tokai University School Of Medicine
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Saito Yuki
Department Of Behavioral Science Tohoku University Graduate School Of Medicine
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Tokuda Y
Aichi Inst. Technol. Toyota Jpn
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Tokuda Yutaka
Depertment Of Electronics Aichi Institute Of Technology
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Tokuda Yutaka
Department Of Surgery Tokai University School Of Medicine
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UMEMURA Shinobu
Cytology and Core Needle Biopsy Subcommittee of the Japanese Breast Cancer Society
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Sugio Yoshinori
Department Of Surgery Tokai University School Of Medicine
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Tanaka Yasuhiko
Department Of Ophthalmology School Of Medicine Keio University
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Suzuki Y
Department Of Surgery Tokai University School Of Medicine
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Saito Yuuki
Department Of Surgery Tokai University School Of Medicine
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Osamura Robert
Department Of Pathology Tokai University School Of Medicine
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Osamura Robert
Department Of Pathology School Of Medicine Tokai University
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Tokuda Yutaka
Department Of Breast And Endocrine Surgery Tokai University School Of Medicine
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Umemura S
Department Of Pathology Tokai University School Of Medicine
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Umemura Shinobu
Department Of Pathology & Division Of Diagnostic Pathology Tokai University School Of Medicine
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Suzuki Yasuhiro
Department Of Breast And Endocrine Surgery Tokai University School Of Medicine
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Umemura S
Tokai Univ. School Of Medicine
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