Expression and Significance of C-Met Protein in Papillary Thyroid Carcinoma
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概要
- 論文の詳細を見る
The c-met protein, encoded by the c-met oncogene and its ligand, the hepatocellular growth factor/scatter factor, are known to be responsible for the motility and mitogenesis of epithelial cells including cancer cells. Recent studies have reported the prognostic significance of the c-met protein in malignant tumors. Papillary thyroid carcinoma, the most common histological type of thyroid carcinoma, can easily metastasize to regional lymph nodes, reflecting the activated motility and invasiveness of the carcinoma cells. We examined the expression of c-met protein in papillary thyroid carcinomas to assess its significance. Immunohistochemical staining of the c-met protein was performed on archival materials. The c-met protein was expressed in 10 cases of papillary thyroid carcinoma with recurrence, and in 5 of 10 cases without recurrence. Normal thyroids were negative for c-met protein. Expression of the c-met protein was statistically associated with recurrence of the thyroid carcinoma (p=0.016). It is suggested that expression of the c-met protein plays a role in the recurrence of papillary thyroid carcinoma.
- 東海大学の論文
著者
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Umemura Shinobu
Department of Pathology, Tokai University School of Medicine
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Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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SAKAI Hideto
Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Me
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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ITO Kouichi
Ito Hospital
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INABA Michiko
Division of Nephrology and Metabolism, Department of Internal Medicine
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ABE Yoshifumi
Division of Nephrology and Metabolism, Department of Internal Medicine
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SATO Haruhiro
Division of Nephrology, Endocrinology, and Metabolism, Department of Medicine, Tokai University Scho
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UMEMURA Shinobu
Cytology and Core Needle Biopsy Subcommittee of the Japanese Breast Cancer Society
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Sakai Hideto
Department Of Nephrology Tokai University
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Sato H
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Inaba Michiko
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Umemura S
Department Of Pathology Tokai University School Of Medicine
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Umemura Shinobu
Department Of Pathology & Division Of Diagnostic Pathology Tokai University School Of Medicine
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Abe Yoshifumi
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Umemura S
Tokai Univ. School Of Medicine
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Sato Haruhiro
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Medicine
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Sato Haruhiro
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
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Sakai Hideto
Division of Nephro-Urology
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