Genetic Predisposing Factors in Non-insulin Dependent Diabetes with Persistent Albuminuria
スポンサーリンク
概要
- 論文の詳細を見る
We designed this study to elucidate a possible involvement of genetic factors which influence the progression of renal dysfunction in patients with non-insulin dependent diabetes mellitus (NIDDM). A total of 328 patients was randomly selected in the Tokai University Hospital. They had been cared for in our hospital as NIDDM for the past five years, until April, 1989. Fifty-six patients with persistent albuminuria, and an equal number of patients without persistent albuminuria were included in this study. No significant differences were observed between the two groups in terms of age, estimated period of illness, blood pressure, body-mass index, HbAlc, blood glucose, total cholesterol, triglyceride level and mean blood pressure. The family histories obtained by questionnaires revealed that there might be some genetic predisposing factors leading to the onset of nephropathy in patients with NIDDM, especially in cases with paternal high blood pressure. It is suggested that paternal hypertension might be related to the development of nephropathy in patients with NIDDM.
- 東海大学の論文
著者
-
Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Suzuki Daisuke
Division of Biological Science, Graduate School of Science, Nagoya University
-
SAKAI Hideto
Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Me
-
Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine
-
Sakai Hideto
東海大学 医学部腎・内分泌・代謝内科
-
TAKEDA Hiroshi
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
OHTA Kazuko
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
HAGIWARA Mayumi
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
HORI Kaoru
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
WATANABE Kazufumi
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
TANAKA Kurumi
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
MACHIMURA Hideo
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
YAGAME Mitsunori
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
KANESHIGE Hideaki
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of M
-
Suzuki Daisuke
東海大学 医学部内科学系腎内分泌代謝内科
-
Suzuki D
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Kawada Tsutomu
Department Of Obsetrics And Gynecology School Of Medicine Tokai University
-
Hori Kaoru
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Ohta Kazuko
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Ohta Kazuko
東海大学 内科
-
Tanaka K
Tokai Univ. School Of Medicine
-
Tanaka Kurumi
東海大学 内科
-
Takeda Hiroshi
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
-
Suzuki D
Hitachi Ltd. Tokyo Jpn
-
Suzuki D
Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya
-
Sakai Hideto
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
-
Suzuki Daisuke
Division Of Biological Science Nagoya University
-
Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
-
Sakai Hideto
Department Of Nephrology Tokai University
-
Takeda Hiroshi
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Sakai Hideto
Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University
-
Sato H
Division Of Nephrology And Metabolism Department Of Internal Medicine
-
Suzuki D
Central Research Laboratory Hitachi Ltd
-
Watanabe K
Tokai Univ. School Of Medicine
-
Tanaka K
Department Of Transplantation I Tokai University School Of Medicine
-
Machimura H
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Machimura Hideo
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Hagiwara Mayumi
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Yagame Mitsunori
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
-
Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
-
Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
-
Suzuki Daisuke
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
-
Watanabe Katsuto
Department Of Pathology School Of Medicine Tokai University
-
Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
-
Sato Haruhiro
Division Of Nephrology And Metabolism Department Of Internal Medicine
-
Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
-
Sakai Hideto
Division of Nephro-Urology
-
Yagame Mitsunori
Division of Nephrology and Metabolism, Department of Internal Medicine, School of Medicine, Tokai University
関連論文
- 1P-243 コレラ菌・海洋ビブリオ菌のアミノ酸走性に関与する受容体ホモログの解析(化学受容,第46回日本生物物理学会年会)
- 2P-281 Salinibacter ruberセンサリーロドプシンI(SRl)変異体を用いた色制御機構の解析(光生物・視覚,光受容(2),第46回日本生物物理学会年会)
- 1P-269 KおよびM中間体形成時におけるSalinibacter sensory rhodops in Iの構造変化(光生物・視覚,光受容(1),第46回日本生物物理学会年会)
- Immunogenetical Study in Patients with Chronic Glomerulonephritis
- Refractory Hemolytic Uremic Syndrome Improved by Plasmapheresis Using Cryosupernatant Fraction as a Replacement Fluid: A Case Report
- Modified Open Renal Biopsy
- Papillary Necrosis and the Antinuclear Factor
- Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-α, -β in human diabetic nephropathy
- Localization of connective tissue growth factor mRNA in human diabetic nephropathy by in situ hybridization
- In-situ hybridizaiton studies of protein kinase C α and β I isoforms in human diabetic nephropathy
- Wegener's Granulomatosis with Relapsed Bleeding of Gastric Ulcers : A Case Report
- Nephrotic Syndrome Associated with Subacute Bacterial Endocarditis (SBE) : A Case Report
- Significance of Superoxide Generation and FcαR Bearing Polymorphonuclear Leukocyte in IgA Nephropathy(The 4th Joint Symposium between Tokai University School of Medicine and Semmelweis University School of Medicine 7-9, June, 1993, Budapest)
- Genetic Predisposing Factors in Non-insulin Dependent Diabetes with Persistent Albuminuria
- CD4 Subsets in IgA Nephropathy
- In Vivo Antibody Response to Mucosal (NASAL) and Subcutaneous Stimulation of Influenza Virus in Patients with IgA Nephropathy
- No Increase in Antibodies to Six Food Antigens in Japanese Patients with IgA Nephropathy
- Eosinophilic Peritonitis Responding to Treatment with Glycyrrhizin
- A Case of Insulin-secreting Tumor Successfully Treated with Diazoxide
- Influenza Antibody Titers after Vaccination of Chronic Renal Failure Patients : before and during Hemodialysis, or on Continuous Ambulatory Peritoneal Dialysis
- Three Cases of Acute Massive Hydrothorax Complicating Continuous Ambulatory Peritoneal Dialysis (CAPD)
- Continuous Ambulatory Peritoneal Dialysis in a Diabetic Patient with Renal Insufficiency and Ventricular Aneurysm
- Rapidly Progressive Glomerulonephritis Undetected by Routine School Urinalysis: A Case Report
- Immunofluorescent Studies on IgA Nephropathy : Type IV Collagen and Glomerular Basement Membrane Component Detected by Goodpasture's Syndrome Serum and Laminin
- Molecular Weights of IgA-circulating Immune Complexes (CIC) in Patients with IgA Nephropathy : Application of HPLC and Solid-phase Anti-C3 Facb EIA
- Detection of Immunoglobulin Depositions by Immunofluorescence and/or Immunoperoxidase (P-AP Method) in Patients with IgA Nephropathy
- Double Immunofluorescence Studies of IgA and Poly C9 (MAC) in Glomeruli from Patients with IgA Nephropathy
- A Case Report of Henoch-Schoenlein Purpura Nephritis Associated with a Postbulbar Duodenal Ulcer
- Hyperosmolar Nonketotic Diabetic State Associated with Disseminated Intravascular Coagulation and Acute Renal Failure : A Case Report
- Impaired Granulocyte Function in Patients with Diabetes Mellitus
- Immunofluorescent Studies on Acute Phase Reactants in Patients with Various Types of Chronic Glomerulonephritis
- 1P-244 コレラ菌走化性関連シグナリングシステムIIIタンパク質の局在制御(化学受容,第46回日本生物物理学会年会)
- Antecedent Thrombolytic Therapy Followed by Planned Rescue PCI for Acute Myocardial Infarction, Compared with Primary PCI
- A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey)
- Evaluation of Renal Biopsy Samples of Patients with Diabetic Nephropathy
- A Diabetic Case with Hemoglobin J-Meerut and Low HbA_ Levels
- Effect of Cisapride on Gastric Emptying in Diabetic Patients without Gastrointestinal Symptoms
- Deteriorative Effect of Smoking on Target Lesion Revascularization After Implantation of Coronary Stents With Diameter of 3.0 mm or Less
- 2P273 細菌型緑色光吸収タンパク質、SRIの構造変化・色制御・情報伝達機構の解析(光生物-視覚・光受容,第48回日本生物物理学会年会)
- Clinical guidelines of IgA nephropathy
- Clinical guidelines for immunoglobulin A (IgA) nephropathy in Japan, second version
- Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide
- Decreased Insulin Binding of Mononuclear Leukocytes in Diabetic Patients with Hyperlipidemia
- Significance of LDL binding Lymphocytes in Patients with Hyperlipidemia
- Expression of RET in follicular cell-derived tumors of the thyroid gland : Prevalence and implication of morphological type
- Expression and Significance of C-Met Protein in Papillary Thyroid Carcinoma
- Expression of connective tissue growth factor mRNA in human IgA nephropathy
- Inhibitory Effect of Thyrotropic Hormone on Apoptosis Induced by Actinomycin D in a Functioning Rat Thyroid Cell Line
- Long-Trem Use of Hemodiafiltration in Two patients Undergoing Continuous Ambulatory Peritoneal Dialysis
- Urinary Albumin Fragments as a New Clinical Parameter for the Early Detection of Diabetic Nephropathy
- Convulsions in Hemodialysis (HD) Patients with Elevated Polymorphonuclear Leukocyte Elastase (PMNE) Levels
- Clinical Effect of Dipyridamole in Patients with IgA Nephropathy
- Siblings with IgA Nephropathy and Diffuse Proliferative Glomerulonephritis (PGN) Associated with Identical HL-A Antigens
- Detection of α2-Pregnancy Associated-Glycoprotein (α2-PAG) in Cultured Human Peripheral Blood Mononuclear Cells
- Successful Use of Continuous Ambulatory Peritoneal Dialysis (CAPD) in the Treatment of Patients with Renal and Cardiac Failure
- An Adult Case of Fanconi's Syndrome Associated with Membranous Nephropathy
- A Case of Mesangial IgM Nephropathy with Decreased Renal Function
- Two Cases of Acute Poststreptococcal Glomerulonephritis Superimposed on Rheumatoid Arthritis
- A Case of Behcet's Disease Associated with Membranous Nephropathy
- Focal Segmental Glomerulosclerosis Associated with a Pheochromocytoma
- Detection of Polymeric IgA in Sera from Patients with IgA Nephropathy Determined by Thin-Layer Gel Filtration
- Solubilization of Intraglomerular Deposits of Serum Proteins by Fresh Human Sera or Gamma-globulin in Patients with Diabetic Nephropathy
- Increase in Proteinuria and/or Microhematuria Following Upper Respiratory Tract Infections in Patients with IgA Nephropathy
- Aberration of B and T Cell Subsets in Patients with IgA Nephropathy and Membranous Nephropathy
- Effects of a "Single Shot" of Urokinase on Fibrinolytic Activities in Patients with IgA Nephropathy
- 1P270 Analysis of the interaction between phototaxis signaling molecules from Salinibacter ruber.(Photobiology:Vision & Photoreception,The 48th Annual Meeting of the Biophysical Society of Japan)
- 3P-214 細菌の光センサーSRIとトランスデューサーHtrlの複合体の性質(光生物-視覚・光受容,第47回日本生物物理学会年会)
- 1P-202 サリニバクターSRIシグナル伝達系を用いた、走光性大腸菌作成に向けた試み(生体膜・人工膜-情報伝達,第47回日本生物物理学会年会)
- Noninvasive Detection of Coronary Stenosis using Multislice Computer Tomography
- Functional Interpretation of the Kidney Juxtaglomerular Apparatus Using Renin Immunohistochemistry in Bartter's, Pseudo-Bartter's and Conn's Syndromes
- Ultrastructural and Biochemical Studies in Human Adrenocortical Adenomas Associated with Primary Aldosteronism
- Enzyme Histo-cytochemical Studies in Human Adrenocortical Adenomas [II] Cushing's Syndrome
- Enzyme Histocytochemical Studies in Human Adrenocortical Adenomas : [I] Primary aldosteronism
- Intestinal bacteria-derived putrefactants in chronic renal failure
- BIOASSAY OF HAIR FOR ESTIMATION OF BODY BURDEN BY TRITIUM EXPOSURE
- Detection of IgA Dominant Immune Complexes on Peripheral Blood Lymphocytes in Patients with IgA Nephropathy
- A Case of Acute Renal Failure Associated with Type A Acute Hepatitis Responds Dramatically to Plasmapheresis
- Cold-reacting Antinuclear Factor in Sera from Patients with Primary Glomerular Diseases
- Detection of Immunoglobulins and/or Complement in Kidney Tissues from Non-obese Diabetic (NOD) Mice
- Levels of Fibrinopeptide A (FPA) and Fibrinopeptide Bβ 15-42 (FPBβ) in Urine and Plasma after Urokinase Administration in Patients with Chronic Glomerulonephritis
- Parameters of Altered Plasma Glucose Levels during Short Intervals in Diabetic Patients
- A Case of Fabry's Disease
- Determination of Tissue Type Plasminogen Activator in the Glomeruli of Patients with IgA Nephropathy
- Short Term Effect of Lactulose Therapy in Patients with Chronic Renal Failure
- Impaired Ca^ Handling in Perfused Hypertrophic Hearts from Dahl Salt-Sensitive Rats
- Effect of taurine on intracellular Ca handling and contractility (Ca-force-frequency relationship) in perfused rat hearts
- Inhibition by KB-R7943 of the Reverse Mode of the Na^+/Ca^ Exchanger Reduces Ca^ Overload in Ischemic-Reperfused Rat Hearts
- Comparative Studies among Morphological Changes of Urinary Sediments and Histopathological Injuries in Patients with IgA Nephropathy
- A nationwide survey of rapidly progressive glomerulonephritis in Japan : etiology, prognosis and treatment diversity
- Two Adult Cases of Ectopic Kidney
- Nonoliguric Acute Renal Failure in Acute Pancreatitis
- Immunological Mechanisms of Cytotoxicity in Patients with Chronic Glomerulonephritis
- IgA Nephropathy Associated with Myasthenia Gravis and Scleritis
- A Case of Granulomatous Renal Sarcoidosis with a Dramatic Response to Corticosteroid and Urokinase Therapy
- Hepatic Glomerulosclerosis with IgA Deposition : Report of Three Cases
- A Case of IgA Nephropathy Associated with Marked Hematuria after Upper Respiratory Tract Infections
- Selective IgM Deficiency: A Case Study
- Deposition of C4-binding Protein and β_1H Globulin in Kidneys of Patients with IgA Nephropathy
- Double Immunofluorescence Studies on IgA-associated Immune-complexes in Glomerular Deposits in Patients with IgA Nephropathy
- Prophylactic Treatment of Hereditary Angioneurotic Edema with Anabolic Steroids