A Case of Fabry's Disease
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概要
- 論文の詳細を見る
A case of Fabry's disease in a 22-year-old male patient who had mild proteinuria and dark-red eruptions is reported. He had been treated as a case of a so-called "chronic glomerulonephritis" for one year. However, histopathological findings of the renal biopsy specimens showed the presence of numerous vacuolated cells in the glomeruli. These vacuolated cells contained numerous electron dense bodies observed by electron microscopy. Skin lesions of this patient were consistent with those of angiokeratoma corporis. The levels of serum alpha-galactosidase were significantly lower than those of healthy controls. The mother of this patient also showed decreased levels of serum alpha-galactosidase. The pedigree of this patient showed a familial history of various types of renal diseases. It was postulated that Fabry's disease occurring in older patients has a worse clinical course. It is concluded that early detection of this disease through biopsy and the assay of serum α-galactosidase levels is important in managing the future course of patients with Fabry's disease.
- 東海大学の論文
著者
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Tomino Yasuhiko
Department Of Internal Medicine School Of Medicine Tokai University
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SUGA Takao
Department of Internal Medicine, School of Medicine, Tokai University
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NOMOTO Yasuo
Department of Internal Medicine, School of Medicine, Tokai University
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ENDOH Masayuki
Department of Internal Medicine, School of Medicine, Tokai University
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SAKAI Hideto
Department of Internal Medicine, School of Medicine, Tokai University
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NAGURA Hiroshi
Department of Pathology, Tohoku University Hospital
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Endoh M
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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MIURA Masahiko
Department of Internal Medicine, School of Medicine, Tokai University
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KANESHIGE Hideaki
Department of Internal Medicine, School of Medicine, Tokai University
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Shinbo Takao
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Inoue Wataru
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Nomoto Yasuo
Department Of Intermal Medicine School Of Medicine Tokai University
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Suga Takao
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Inoue Wataru
Department Of Intelligence Science And Technology Graduate School Of Informatics Kyoto University
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MATSUO Itsuro
Department of Dermatology Teikyo University School of Medicine
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Sakai Hideto
Department Of Intermal Medicine School Of Medicine Tokai University
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IKEDA Noriyuki
Clinical Laboratory, School of Medicine, Tokai University
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Ikeda Noriyuki
Department Of Clinical Laboratory School Of Medicine Tokai University
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Sakai Takako
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Nagura Hiroshi
Department Of Pathology Tohoku University Graduate School Of Medicine
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Matsuo Itsuro
Department Of Dermatology School Of Medicine Tokai University
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Miura Masahiko
Department Of Internal Medicine School Of Medicine Tokai University
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Suga Takao
Department Of Internal Medicine School Of Medicine Tokai University
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Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Nagura Hiroshi
Department Of Neurology Tokyo Metropolitan Geriatric Hospital
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Nagura Hiroshi
Department Of Pathology School Of Medicine Tokai University
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Tomino Yasuhiko
Department Of Internal Medicine Fujita Health University
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Suga Takao
Division Of Nephrology Department Of Internal Medicine Tokai University Oiso Hospital
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Tomino Yasuhiko
Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine
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Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Kaneshige Hideaki
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai University
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai University
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Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
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Miura Masahiko
Department of Dental Radiology and Radiation Research, Faculty of Dentistry, Tokyo Medical and Dental University
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MATSUO ITSURO
Department of Biochemistry and Department of Dermatology, School of Medicine, Keio University
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Inoue Wataru
Department of Electrical and Electronic Engineering, National Defense Academy, 1-10-20 Hashirimizu, Yokosuka, Kanagawa 239-8686, Japan
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