Molecular Weights of IgA-circulating Immune Complexes (CIC) in Patients with IgA Nephropathy : Application of HPLC and Solid-phase Anti-C3 Facb EIA
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概要
- 論文の詳細を見る
The detection of molecular weights of IgA-circulating immune complexes (CIC) in sera is described. Measurement of IgA-, IgG- and IgM-CIC in sera was also performed. Serum samples were obtained from nine patients with IgA nephropathy, nine patients with chronic proliferative glomerulonephritis without IgA deposits (PGN) and 19 healthy adults. Serum samples of these patients were subjected to high performance liquid chromatography (HPLC) and then divided into 50 fractions. Measurement of IgA-, IgG- and IgM-CIC in such fractions was performed using solid-phase anti-C3 Facb EIA. The levels of IgA-CIC in sera from patients with IgA nephropathy were significantly higher than those from patients with PGN or healthy adults. The peak values of molecular weights of IgA-CIC in sera from patients with IgA nephropathy ranged from 2.6×10^5 to 3.0×10^5 daltons (mean±SD; 2.9±2.0). It was suggested that the increase of IgA-CIC in sera from patients with IgA nephropathy may be mainly due to dimers and/or polymers.
- 東海大学の論文
著者
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Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Tomino Yasuhiko
Department Of Internal Medicine School Of Medicine Tokai University
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Tomino Yasuhiko
順天堂大学 腎臓内科学
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NOMOTO Yasuo
Department of Internal Medicine, School of Medicine, Tokai University
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SAKAI Hideto
Department of Internal Medicine, School of Medicine, Tokai University
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Nomoto Yasuo
Departments Of Nephrology And Metabolism; School Of Medicine Tokai University
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Tomino Y
Division Of Nephrology Department Of Internal Medicine Juntendo University School Of Medicine
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EGUCHI Kazuhiko
Department of Internal Medicine, School of Medicine, Tokai University
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YAGAME Mitsunori
Department of Internal Medicine, School of Medicine, Tokai University
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SUGUKI Hideaki
Teijin Institute for Bio-medical Research
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HOSODA Kenji
Teijin Institute for Bio-medical Research
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Nomoto Yasuo
Department Of Intermal Medicine School Of Medicine Tokai University
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Eguchi K
Department Of Medicine Tokai University School Of Medicine
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Sakai Hideto
Department Of Intermal Medicine School Of Medicine Tokai University
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Nomoto Yasuo
Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University
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Sakai Hideto
Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University
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Yagame Mitsunori
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Tomino Yasuhiko
Department Of Internal Medicine Fujita Health University
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Tomino Yasuhiko
Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Sato Haruhiro
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
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