Immunogenetical Study in Patients with Chronic Glomerulonephritis

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概要

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• HLA-A, B and DR typing was performed on a total of 236 patients with chronic glomerulonephritis (CGN) which were diagnosed by renal biopsies evaluated by light microscopy, direct immunofluorescent staining and whenever indicated electron microscopy. The interrelationship between the HLA system and the histopathologic classification of CGN was examined. There were 20 patients with benign recurrent hematuria (BRH), 82 with IgA nephropathy (IgA-N), 24 with proliferative glomerulonephritis (PGN), 47 with minimal change nephrotic syndrome (MCNS), 4 with membranous nephropathy (MN), 43 with membranoproliferative glomerulonephritis (MPGN) and 16 with focal glomerulosclerosis (FGS). The following results were obtained : 1) Antigens from different loci were associated with different subgroups of CGN. There were three types of associations; a) HLA-A locus associated as found in PGN, b) HLA-B locus associated as found in BRH and c) HLA-DR locus associated as found in MCNS. IgA-N, MPGN and FGS seemed to be included in this group. 2) The association of HLA-A locus antigens with MCNS could be subdivied by age of onset suggesting that in MCNS HLA-A antigens are linked to disease expression. 3) A heterogeneity in IgA-N is suggested by its association with different HLA antigens; a) a HLA-B37 associated group, b) a HLA-DR4 or DYT associated group and c) a HLA-DEn (Dw 6.1) or B12 associated group. These data suggest differences in the mechanisms of HLA and disease association in each histopathologic subtype of CGN.

著者

• ITOH Hiroshi

  Department of Internal Medicine, Keio University School of Medicine

• Tomino Yasuhiko

  Department Of Internal Medicine School Of Medicine Tokai University

• NOMOTO Yasuo

  Department of Internal Medicine, School of Medicine, Tokai University

• SAKAI Hideto

  Department of Internal Medicine, School of Medicine, Tokai University

• Sakai Hideto

  Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med

• Nomoto Yasuo

  Department Of Intermal Medicine School Of Medicine Tokai University

• Itoh Hiroshi

  Department Of Astronomy Kyoto University

• TSUJI Kimiyoshi

  Department of Transplantation Immunology, Tokai University School of Medicine

• KOMORI Kiyotaka

  Department of Transplantation, Tokai University

• NOSE Yoshisuke

  Department of Transplantation, Tokai University

• INOUYE Hiroo

  Department of Transplantation, Tokai University

• IWAGAKI Hiroyuki

  Department of Pediatrics, School of Medicine, Tokai University

• HASEGAWA Osamu

  Division of Pediatric Nephrology, Tokyo Metropolitan Children's Hospital at Kiyose

• Sakai Hideto

  Department Of Intermal Medicine School Of Medicine Tokai University

• Tsuji Kimiyoshi

  Department Of Transplantation Tokai University

• Tsuji Kimiyoshi

  Department Of Transplantation Ii School Of Medicine Tokai University

• Nomoto Yasuo

  Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University

• Iwagaki Hiroyuki

  Department Of Pediatrics School Of Medicine Tokai University

• Inouye Hiroo

  Department Of Transplantation Tokai University

• Nose Yoshisuke

  Department Of Transplantation Tokai University

• Komori Kiyotaka

  Department Of Transplantation Tokai University

• Sakai Hideto

  Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive

• Hasegawa Osamu

  Division Of Pediatric Nephrology Tokyo Metropolitan Children's Hospital At Kiyose

• Tomino Yasuhiko

  Department Of Internal Medicine Fujita Health University

• Tomino Yasuhiko

  Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine

• Itoh Hiroshi

  Department Of Aeronautics And Astronautics The University Of Tokyo

• Itoh Hiroshi

  Department Of Transplantation Tokai University

• Itoh Hiroshi

  Department Of Advanced Materials Science Faculty Of Engineering Kagawa University

• Sakai Hideto

  Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba

• TSUJI KIMIYOSHI

  Department of Radiology, School of Medicine, Keio University

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