Double Immunofluorescence Studies of IgA and Poly C9 (MAC) in Glomeruli from Patients with IgA Nephropathy
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概要
- 論文の詳細を見る
Double immunofluorescent studies on IgA, poly (MAC) or C3 in glomeruli from patients with IgA nephropathy are described. Renal biopsy specimens were obtained from 12 patients with IgA nephropathy, four patients with proliferative glomerulonephritis (PGN) and two normal human kidney (NHK). These specimens were incubated with monoclonal anti-poly C9 (membrane attack complex; MAC) and then stained with FITC-labelled goat anti-mouse immunoglobulin (Ig) antiserum. After washing with phosphate buffered saline (PBS) (pH 7.4), the sections were stained with rhodamine-labelled rabbit anti-human IgA antiserum and examined by fluorescence microscopy. The sections were also stained with FITC-labelled goat anti-human C3 antiserum and then stained with rhodamine-labelled rabbit anti-human IgA antiserum. Markedly combined depositions of IgA and poly C9 or C3 in glomeruli were observed in patients with IgA nephropathy. There was a significant correlation between the deposition of poly C9 and the grading of histopathological injuries in such patients. There was also a significant correlation between the deposition of poly C9 in the extraglomerular vascular vessels and the ageing in patients with IgA nephropathy, PGN and NHK. It appears that the deposition of poly C9 might detect directly the activities of complement in glomeruli from patients with IgA nephropathy.
- 東海大学の論文
著者
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Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Tomino Yasuhiko
Department Of Internal Medicine School Of Medicine Tokai University
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Tomino Yasuhiko
順天堂大学 腎臓内科学
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SUGA Takao
Department of Internal Medicine, School of Medicine, Tokai University
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NOMOTO Yasuo
Department of Internal Medicine, School of Medicine, Tokai University
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ENDOH Masayuki
Department of Internal Medicine, School of Medicine, Tokai University
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SAKAI Hideto
Department of Internal Medicine, School of Medicine, Tokai University
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Nomoto Yasuo
Departments Of Nephrology And Metabolism; School Of Medicine Tokai University
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Endoh M
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Endoh Masayuki
東海大学 医学部腎代謝内科
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Tomino Y
Division Of Nephrology Department Of Internal Medicine Juntendo University School Of Medicine
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MIYAZAKI Masanobu
Department of Internal Medicine, Tokai University School of Medicine
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MIURA Masahiko
Department of Internal Medicine, School of Medicine, Tokai University
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EGUCHI Kazuhiko
Department of Internal Medicine, School of Medicine, Tokai University
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YAGAME Mitsunori
Department of Internal Medicine, School of Medicine, Tokai University
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TAKIURA Fumiaki
Department of Internal Medicine, School of Medicine, Tokai University
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Shinbo Takao
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Nomoto Yasuo
Department Of Intermal Medicine School Of Medicine Tokai University
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Suga Takao
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Eguchi K
Department Of Medicine Tokai University School Of Medicine
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Sakai Hideto
Department Of Intermal Medicine School Of Medicine Tokai University
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TAKEMURA Fumio
Division of Nephrology, Department of Internal Medicine, Tokai university Oiso Hospital
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Nomoto Yasuo
Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University
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Sakai Takako
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Miura Masahiko
Department Of Internal Medicine School Of Medicine Tokai University
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Takemura F
Mechanical Engineering Laboratory
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Yagame Mitsunori
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Suga Takao
Department Of Internal Medicine School Of Medicine Tokai University
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Miyazaki Masanobu
Department Of Internal Medicine Division Of Nephrology And Rheumatology Aichi Medical University Sch
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Tomino Yasuhiko
Department Of Internal Medicine Fujita Health University
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Suga Takao
Division Of Nephrology Department Of Internal Medicine Tokai University Oiso Hospital
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Tomino Yasuhiko
Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Sato Haruhiro
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai University
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Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
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Miura Masahiko
Department of Dental Radiology and Radiation Research, Faculty of Dentistry, Tokyo Medical and Dental University
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