The Sharing of Target-Epitopes between Human Anti-ABO Hemagglutinating and Anti-Pig (Xeno) Endothelium or Anti-Pig Thyroglobulin Antibodies
スポンサーリンク
概要
- 論文の詳細を見る
To select congenial pairs between donor-pig and recipient-human for the future xenotransplantation, the levels of xeno-IgM natural antibodies (NAb) were analyzed in healthy subjects and hemodialysis patients by ELISA tests, which target swine-derived crude endothelial cells (P16N) or proteins (thyroglobulin; TG). The total IgM concentration was lower in hemodialysis patients than in healthy subjects, but there was no difference in IgM NAb titer between the two groups. Individuals with non-B blood types (A, O) exibited significantly higher IgM NAb titer compared with those with B blood types (B, AB). A blood type individuals showed higher killing activity against P16N than those with B, AB or O types with a statistical significance. Sera from A blood type, after being absorbed with red blood cells (RBC) from B blood type, decreased their IgM titer against TG to the level of sera from B blood type. Meanwhile, sera from A blood type significantly decreased hemagglutinin titer against B-RBC after passage through a TG-coated affinity column. We conclude that human anti-B-RBC and anti-Pig xeno NAb have certain common binding epitopes, which might be a branched B carbohydrate structure.
- 東海大学の論文
著者
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SAITO AKIRA
Department of Pediatrics, Hirosaki University School of Medicine
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SAKAI Hideto
Department of Internal Medicine, School of Medicine, Tokai University
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Hagihara Masao
Department Of Hematology And Oncology Tokai University School Of Medicine
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TSUJI Kimiyoshi
Department of Transplantation Immunology, Tokai University School of Medicine
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Sakai Hideto
Department Of Intermal Medicine School Of Medicine Tokai University
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Sakai Hideto
Department Of Nephrology Tokai University School Of Medicine
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MORITA Naokatsu
Department of Nephrology, Tokai University School of Medicine
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KANAI Nobuyuki
Department of Transplantation Immunology, Tokai University School of Medicine
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HIRAGA Seigo
Social Insurance Associations Mishima Hospital
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Morita Naokatsu
Department Of Nephrology Tokai University School Of Medicine:transplantation Immunology Tokai Univer
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Tsuji K
Department Of Transplantation Immunology Tokai University School Of Medicine
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Tsuji Kimiyoshi
Department Of Transplantation Ii School Of Medicine Tokai University
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Kanai Nobuyuki
Department Of Transplantation Immunology Tokai University School Of Medicine:first Department Of Sur
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Kanai Nobuyuki
Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University
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Saito Akira
Department Of Pathology Juntendo University Urayasu Hospital
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Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
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Saito Akira
Department Of Neurosurgery Nagahama Red Cross Hospital
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Saito Akira
Department of Biological Chemistry, Yamaguchi University
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Saito Akira
Department of Applied and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University
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TSUJI KIMIYOSHI
Department of Radiology, School of Medicine, Keio University
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