Progressive Glomerulonephritis with Increasing Proteinuria Induced by a Second Attack to the Mesangial Cell
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概要
- 論文の詳細を見る
We have previously reported that two consecutive injections of the anti-Thy 1.1 monoclonal antibody (mAb) 1-22-3 with an interval of two weeks causes irreversible mesangial alterations. However, the precise mechanism of the development of these alterations was not fully elucidated. In this study, we first investigated the prognosis of rats receiving the second intravenous injection of the mAb 1-22-3 at five weeks after the first injection when the amount of urinary protein excretion normalized. Two consecutive injections of mAb with an interval of five weeks also caused irreversible mesangial alterations with persistent proteinuria (155.8±148.7mg/day at six months). To analyze the mechanism of the development of these alteration, we then compared the acute phase alterations after the second injection (two injection group) with those after the first injection (single injection group). Although no difference in the staining intensity of bound mAb 1-22-3, rat C3 in glomeruli and serum CH50 levels at 30 min after the last anti-Thy 1.1 mAb injection was detected in either group, the number of neutrophils infiltrating into glomeruli 30 min after the first injection of anti-Thy 1.1 mAb was larger than that at 30 min after the second injection (8.7±3.5 vs. 2.2±0.8 / gcs, p=0.0039). Additionally, the numbers of ED3 positive cells and CD8 positive cells infiltrating into glomeruli were significantly larger at five days after the second injection (two injection group) than after the first injection (single injection group). The results show that polymorphonuclear leukocyte (PMN) does not contribute to the progression of chronic glomerular lesions and that activated macrophages (ED3 positive cells) and CD8 positive cells are involved in the development and the progression of chronic glomerular lesions.
- 新潟大学の論文
著者
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SUZUKI Koichi
Department of Pediatrics, Hirosaki University School of Medicine
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SAITO AKIRA
Department of Pediatrics, Hirosaki University School of Medicine
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Kawachi Hiroshi
Department of Pathology, Metropolitan Komagome Hospital
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Shimizu Fujio
新潟大学大学院医歯学総合研究科附属腎研究施設 分子病態学
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Shimizu Fujio
Niigata Seiryo University
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SHIMIZU Fujio
Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine
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Han Gi
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Koike Hiroko
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Kawachi H
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Kawachi Hiroshi
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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KARASAWA Tamaki
Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,
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MIYAUCHI Naoko
Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,
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FUJIOKA Yumiko
Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,
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Suzuki Koichi
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
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Han Gi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Shimizu F
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Fujioka Yumiko
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Miyauchi Naoko
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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Shimizu Fujio
Department Of Applied Physics University Of Tokyo
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Karasawa Tamaki
Department Of Cell Biology Institute Of Nephrology:division Of Pediatrics Graduate School Of Medical
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Kawachi Hiroshi
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Kawachi Hiroshi
新潟大学医学部附属腎研究施設
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Kawachi Hiroshi
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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Shimizu Fujio
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Suzuki Koichi
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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Saito Akira
Department Of Pathology Juntendo University Urayasu Hospital
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Saito Akira
Department of Biological Chemistry, Yamaguchi University
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Saito Akira
Department of Applied and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University
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