Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats
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概要
- 論文の詳細を見る
We aimed to investigate the effects of early intervention in reducing dietary protein intake on chronic progressive GN (glomerulonephritis) by using an irreversible mesangioproliferative GN model. An irreversible mesangioproliferative GN model was induced by two injections of monoclonal anti Thy-1 antibody 1-22-3 two weeks apart. In Experiment 1, 10 rats were divided into a low protein diet (LPD: 6.4% protein) group and a normal protein diet (NPD: 25.4% protein) group. In Experiment 2, another 10 rats were divided into a high protein diet (HPD: 52.5% protein) group and an NPD group. After 10 weeks of administering an experimental diet, the rats were sacrificed to undergo blood biochemistry, light microscopy, and immunofluorescence analyses of the kidneys as well as a glomerular mRNA study. In the LPD group, urinary protein excretion and the expression of collagen type-I mRNA and protein all significantly decreased in comparison with the NPD group. In addition, the mesangial matrix expansion and the glomerular expression of α-smooth muscle actin (α-SMA) and transforming growth-factor-β (TGF-β) mRNA in the LPD group were lower than those in NPD group. However, in the HPD group, both TGF-β and collagen type-I glomerular mRNA expression were higher. The LPD therapy from the early stages of renal dysfunction can be considered effective in preventing further progression of the disease to chronic renal failure.
- 新潟大学の論文
著者
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SUZUKI Koichi
Department of Pediatrics, Hirosaki University School of Medicine
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Kawachi Hiroshi
Department of Pathology, Metropolitan Komagome Hospital
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Shimizu Fujio
新潟大学大学院医歯学総合研究科附属腎研究施設 分子病態学
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Shimizu Fujio
Niigata Seiryo University
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SHIMIZU Fujio
Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine
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Han Gi
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Koike Hiroko
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Kawachi H
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Kawachi Hiroshi
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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Kawachi Hiroshi
Department Of Pathology Metropolitan Komagome Hospital
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FUJIOKA Yumiko
Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,
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NAKATSUE Takeshi
Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,
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Suzuki Koichi
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
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Han Gi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Shimizu F
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Fujioka Yumiko
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Nakatsue Takeshi
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Shimizu Fujio
Department Of Applied Physics University Of Tokyo
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Kawachi Hiroshi
Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni
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Kawachi Hiroshi
新潟大学医学部附属腎研究施設
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Kawachi Hiroshi
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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Shimizu Fujio
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Suzuki Koichi
Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And
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KOIKE Hiroko
Department of Biology, College of Liberal Arts, Saitama University
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