A Novel Rat Model with Podocyte Injury in Developing Stage Glomeruli

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概要

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• Recent investigations have revealed that growth in utero might be an important determinant of adult disorders. The number of nephrons in humans is determined in utero. It is reported that infants who show signs of intrauterine growth retardation (IUGR) at birth have a significant reduction in nephron number and have a high risk for several kidney diseases. The glomerular epithelial cell (podocyte) plays a critical role in maintaining the function and the tuft architecture of glomeruli. In this study, we aimed to establish a rat model with podocyte injury in the developing stage. Five-day-old rats were treated with puromycin aminonucleoside (PAN), which is accepted to have toxicity to podocytes since glomerular maturation lasts after birth in rats, and 5-day-old rats correspond to the late gestational stage in humans. Podocyte injury and its maturity were assessed by the staining of the podocyte functional molecules, nephrin and podocin. In the normal infant rats, nephrin and podocin in podocytes are observed in a continuous linear pattern at the early capillary loop stage. At 24 h after PAN injection, the staining of nephrin and podocin at this stage of glomeruli shifted to a discontinuous pattern, and their staining intensity clearly decreased. Podocyte injury suffered at developing stage of glomeruli resulted in the reduction of podocyte numbers, the compensatory glomerular hypertrophy, and the retardation of any increase in body weight. The model could serve as a mimic of infants who evidence signs of IUGR at birth. The model is suitable to investigate the relation between podocyte injury suffered at the early developing stage and the risk for several kidney diseases in adulthood.

• 新潟大学の論文

著者

• Uchiyama Makoto

  Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu

• Kawachi Hiroshi

  Department of Pathology, Metropolitan Komagome Hospital

• Shimizu Fujio

  新潟大学大学院医歯学総合研究科附属腎研究施設 分子病態学

• Shimizu Fujio

  Niigata Seiryo University

• SHIMIZU Fujio

  Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine

• Han Gi

  Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni

• Koike Hiroko

  Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni

• Uchiyama M

  Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu

• Kawachi H

  Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni

• Kawachi Hiroshi

  Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And

• Kawachi Hiroshi

  Department Of Pathology Metropolitan Komagome Hospital

• KARASAWA Tamaki

  Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,

• MIYAUCHI Naoko

  Department of Cell Biology, Institute of Nephrology, Graduate School of Medical and Dental Sciences,

• HASHIMOTO Taeko

  Department of Cell Biology, Institute of Nephrology

• HARITA Yutaka

  Department of Cell Biology, Institute of Nephrology

• Uchiyama Makoto

  Division Of Pediatrics Graduate School Of Medical And Dental Sciences Niigata University

• Uchiyama Makoto

  Division Of Pediatrics Department Of Homeostatic Regulation And Development Course For Biological Fu

• Han Gi

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App

• Harita Yutaka

  Department Of Cell Biology Institute Of Nephrology

• Shimizu F

  Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni

• Miyauchi Naoko

  Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And

• Shimizu Fujio

  Department Of Applied Physics University Of Tokyo

• Karasawa Tamaki

  Department Of Cell Biology Institute Of Nephrology:division Of Pediatrics Graduate School Of Medical

• Hashimoto Taeko

  Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And

• Kawachi Hiroshi

  Department Of Cell Biology Institute Of Nephrology Graduate School Of Medical And Dental Sciences Ni

• Kawachi Hiroshi

  新潟大学医学部附属腎研究施設

• Kawachi Hiroshi

  Department Of Cell Biology Institute Of Nephrology Niigata University Graduate School Of Medical And

• Shimizu Fujio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• KOIKE Hiroko

  Department of Biology, College of Liberal Arts, Saitama University

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