Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells
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概要
- 論文の詳細を見る
To evaluate the involvement between Fasassociated phosphatase-1 (FAP-1) and drug resistance, the expression of FAP-1 in leukemic cell lines, drugresistant sublines, and leukemic cells was examined by RT-PCR. In comparison with the parental cell line (KY-821), arabinofuranosylcytosine (ara-C)-resistant subline (KY-Ra), and vincristine (VCR)-resistant subline (KY-VCR) showed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. Leukemic cell lines (KY-821 and Jurkat) revealed an increase in FAP-1 expression after exposure to ara-C (1×10^<-5>M) and VCR (1×10^<-7>M). Furthermore, after exposure to anticancer drugs at low dosages for five days, both KY-821 and Jurkat revealed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. In study with de novo leukemic cells, two cases showed an increase in FAP-1 expression after exposure to anticancer drugs, of which one revealed an increased resistance to anti-CD95 antibody-induced apoptosis. These results indicate a close involvement between CD95-mediated apoptosis and drug resistance, and suggest that anticancer drugs suppress CD95-mediated apoptosis in part by inducing FAP-1 overexpression in some leukemic cells.
- 新潟大学の論文
著者
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KAKIHARA TOSHIO
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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IMAI CHIHAYA
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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TANAKA ATSUSHI
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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Uchiyama Makoto
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Imamura Masaru
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Uchiyama M
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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KOBAYASHI Takehiro
Division of Pediatrics, Department of Homeostatic Regulation and Development, Graduate School of Med
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Kobayashi Takehiro
Division Of Pediatrics Department Of Homeostatic Regulation And Development Graduate School Of Medic
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Tanaka A
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Uchiyama Makoto
Division Of Pediatrics Department Of Homeostatic Regulation And Development Course For Biological Fu
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Imai Chihaya
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Kakihara T
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Imamura Masaru
Division Of Cellular And Molecular Pathology Department Of Cellular Function Niigata University Grad
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Kakihara Toshio
Department Of Paediatrics Niigata University School Of Medicine
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Kobayashi T
Niigata Univ. Niigata Jpn
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Kakihara Toshio
Departments Of Pediatrics
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Tanaka Atsushi
Division Of Gastroenterology The Institute For Adult Diseases Asahi Life Foundation
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Kakihara Toshio
Department Of Pediatrics Niigata University School Of Medicine
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