<Original article>The Relationship of Serum Levels of Malondialdehyde-modified Low Density Lipoprotein to Serum Lipids and Anthropometric Measurements in School Children
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概要
- 論文の詳細を見る
The aim of this study was to reveal the serum levels of malondialdehyde-modified LDL (MDA-LDL), which is one of the oxidative LDL, and the relationships of serum MDA-LDL to serum lipids and apolipoproteins, and obesity in children. Japanese school boys (36 obese and 101 nonobese) and girls (24 obese 111 nonobese) aged from 10 to 14 years were examined. Serum MDA-LDL levels were measured by the double-antibody sandwich ELISA method. Serum LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglycerid (TC), apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), and apolipoprotein E (Apo E) levels were measured using an automatic analyzer. Height and weight were measured, and percent of relative weight, body mass index (BMI), were calculated. The serum MDA-LDL levels were 58.9±6.8 U/1 (obese, 68.3±24.1 IU/l; nonobese, 55.6±16.2) in boys and 56.3±19.5 U/l (obese, 62.9±27.5 IU/l; nonobese, 54.9±17.1) in girls. The serum MDA-LDL levels in obese boys were significantly higher than those in nonobese boys (p<0.001). The serum MDA-LDL levels in obese girls had a tendency to be higher than those in nonobese girls (p=0.06). In both sexes, the serum MDA-LDL levels showed a significantly positive correlation with serum LDL-C, TC, Apo B and Apo E levels and percent of relative weight, BMI, and showed a significantly inverse correlation with the serum HDL-C levels. Children with dyslipidemia and/or obesity might already have higher MDA-LDL levels and atherosclerotic lesions. They therefore should be monitored for the prevention of atherosclerotic disease from childhood.
- 新潟大学の論文
著者
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Kikuchi Toru
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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UCHIYAMA MAKOTO
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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Uchiyama Makoto
新潟大学 医歯学総合研究科小児科学
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Uchiyama Makoto
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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HIURA Makoto
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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KAMEDA Kazuhiro
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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YAMAZAKI Hisashi
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Gra
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Uchiyama M
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Uchiyama Makoto
Division Of Pediatrics Department Of Homeostatic Regulation And Development Course For Biological Fu
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Hiura Makoto
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Yamazaki Hisashi
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Kikuchi Toru
Department Of Pediatrics School Of Medicine Niigata University
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Uchiyama Makoto
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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Kameda Kazuhiro
Division Of Pediatrics Department Of Homeostatic Regulation And Development Niigata University Gradu
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