<Original article>The Relationship of Serum Levels of Malondialdehyde-modified Low Density Lipoprotein to Serum Lipids and Anthropometric Measurements in School Children

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The aim of this study was to reveal the serum levels of malondialdehyde-modified LDL (MDA-LDL), which is one of the oxidative LDL, and the relationships of serum MDA-LDL to serum lipids and apolipoproteins, and obesity in children. Japanese school boys (36 obese and 101 nonobese) and girls (24 obese 111 nonobese) aged from 10 to 14 years were examined. Serum MDA-LDL levels were measured by the double-antibody sandwich ELISA method. Serum LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglycerid (TC), apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), and apolipoprotein E (Apo E) levels were measured using an automatic analyzer. Height and weight were measured, and percent of relative weight, body mass index (BMI), were calculated. The serum MDA-LDL levels were 58.9±6.8 U/1 (obese, 68.3±24.1 IU/l; nonobese, 55.6±16.2) in boys and 56.3±19.5 U/l (obese, 62.9±27.5 IU/l; nonobese, 54.9±17.1) in girls. The serum MDA-LDL levels in obese boys were significantly higher than those in nonobese boys (p<0.001). The serum MDA-LDL levels in obese girls had a tendency to be higher than those in nonobese girls (p=0.06). In both sexes, the serum MDA-LDL levels showed a significantly positive correlation with serum LDL-C, TC, Apo B and Apo E levels and percent of relative weight, BMI, and showed a significantly inverse correlation with the serum HDL-C levels. Children with dyslipidemia and/or obesity might already have higher MDA-LDL levels and atherosclerotic lesions. They therefore should be monitored for the prevention of atherosclerotic disease from childhood.
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