In Vivo Antibody Response to Mucosal (NASAL) and Subcutaneous Stimulation of Influenza Virus in Patients with IgA Nephropathy
スポンサーリンク
概要
- 論文の詳細を見る
Anomalies in the production of antibodies have been postulated in the development of IgA nephropathy. In order to study the aberrant immune response in patients with IgA nephropathy (IgAN), an influenza virus vaccine was administered to healthy adults and patients with IgAN to demonstrate if there was any in vivo alteration in the antibody production to mucosal and non-mucosal antigenic stimulation in these groups. The vaccine was administered subcutaneously (s.c) or intranasally at a dose of 350 CCA or 1,050 CCA at an interval of 4 weeks, respectively. IgG, IgA, IgM class antibodies to influenza virus were determined using the enzyme linked immunosorbent assay (ELISA). Subcutaneous stimulation induced IgM antibody response in both groups. However, positive response to nasal stimulation was observed only in the patient group. Serum IgA and IgM responses in the patient group were significantly higher than those in the control group. These data suggested that patients with IgA nephropathy showed higher antibody response to mucosal stimulation than healthy controls.
- 東海大学の論文
著者
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Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Kashem Abul
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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YAMAUCHI Fumio
Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Me
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ENDOH Masayuki
Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Me
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NOMOTO Yasuo
Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Me
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SAKAI Hideto
Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Me
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Nomoto Yasuo
Departments Of Nephrology And Metabolism; School Of Medicine Tokai University
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Sakai H
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Sakai Hideto
東海大学 医学部腎・内分泌・代謝内科
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Endoh M
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Endoh Masayuki
東海大学 医学部腎代謝内科
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Endoh Masayuki
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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YANO Naohiro
Division of Nephrology and Metabolism, Department of Internal Medicine
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Yano Naohiro
The Division Of Nephroloty And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Yano Naohiro
東海大学 内科
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Yamauchi F
Tohoku Univ. Sendai‐shi
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Yamauchi Fumio
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Yamauchi F
Department Of Food Chemistry Faculty Of Agriculture Tohoku University
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Sakai Hideto
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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Nomoto Yasuo
Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Sakai Hideto
Division Of Nephrology Department Of Internal Medicine School Of Medicine Tokai University
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Sato H
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Sakai Hideto
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Nomoto Yasuo
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai U
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Sato Haruhiro
Division Of Nephrology And Metabolism Department Of Internal Medicine
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Endoh Masayuki
The Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai University
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Sakai Hideto
Department Of Health Care Policy And Management Graduate School Of Comprehensive Sciences University Of Tsukuba
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Sakai Hideto
Division of Nephro-Urology
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Kashem Abul
Division of Cardiothoracic Surgery, Temple University School of Medicine
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