Expression of Prolactin-Receptor mRNA in Mammary Adenocarcinoma of a F344 Rat
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概要
- 論文の詳細を見る
Both long and short forms of Prolactin-receptor (PRL-R) mRNA were detected in a spontaneous mammary adenocarcinoma of an aged female F344 rat, using sensitive techniques, reverse transcriptase-polymerase chain reaction (RT-PCR), and in situ hybridization (ISH). Amplified products of the long form of PRL-R were markedly identified by RT-PCR, and the mRNA was diffusely exhibited in the cytoplasm of neoplastic epithelium by ISH. Additionally, the long form of PRL-R mRNA was exhibited in the normal mammary tissue surrounding the neoplasm. However, amplified products of the short form of PRL-R were weakly detected by RT-PCR, and the mRNA was not detected in either normal tissue or the neoplasm by ISH. PRL-R mRNA was detected in the rat spontaneous malignant mammary neoplasm and the long form of PRL-R was more highly expressed than the short form.
- 日本毒性病理学会の論文
- 1999-06-01
著者
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MIYAJIMA Katsuhiro
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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OSAMURA R.
Department of Pathology, Tokai University School of Medicine
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Kakimoto Kochi
Department of Pathology Tokai University School of Medicine
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Umemura Shinobu
Department of Pathology, Tokai University School of Medicine
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KOIZUMI Haruko
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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TAKAHASHI Akemi
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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MIYAKAWA Yoshifumi
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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Takahashi A
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Koizumi H
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Koizumi Haruko
日本たばこ産業
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Osamura Robert
Dep. Of Pathology Tokai Univ. School Of Medicine
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Osamura R.
Department Of Pathology School Of Medicine Tokai University
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Takahashi Akemi
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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IWASAKA Toshiki
Department of Pathology, Tokai University School of Medicine, Toxicology Research Laboratories, Cent
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Osamura R
Tokai Univ. School Of Medicine Kanagawa Jpn
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Osamura R.yoshiyuki
Department Of Pathology Tokai University School Of Medicine
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Osamura R.
Tokai Univ. School Of Medicine Kanagawa Jpn
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Umemura Shinobu
Department Of Pathology & Division Of Diagnostic Pathology Tokai University School Of Medicine
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Hitoshi Koizumi
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Iwasaka Toshiki
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Koizumi Haruko
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Toxicology Res. Laboratories Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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Osamura R
Tokai Univ. School Of Medicine
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Iwasaka Toshiki
Department Of Pathology Tokai University School Of Medicine
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Miyakawa Yoshifumi
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Japan Tobacco Inc. Central Pharmaceutical Research Institute Toxicology Research Laboratories
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Umemura S
Tokai Univ. School Of Medicine
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Takahashi Akemi
Toxicology Research Lab. Central Pharmaceutical Research Institute Japan Tobacco Inc.
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