Spontaneous Histiocytic Sarcoma of the Popliteal Lymph Node in a Young Sprague-Dawley Rat
スポンサーリンク
概要
- 論文の詳細を見る
The present report describes a rare case of spontaneous primary histiocytic sarcoma of the popliteal lymph node in a 19-week-old female Sprague-Dawley (SD) rat. At necropsy, a 10 mm-diameter whitish nodule was found at the site of the femoral muscle in the right hindlimb. Histopathologically, the nodule comprised large pleomorphic histiocyte-like cells with abundant eosinophilic or foamy cytoplasm. Multinucleated giant cells, necrotic foci surrounded by palisading arrays of epithelioid histiocyte-like cells and phagocytosis of cell debris or erythrocytes by the neoplastic cells were occasionally observed. Invasion of the tumor cells into the surrounding adipose tissue was found focally, but there were no distal metastases. Immunohistochemically, the neoplastic cells were positive for vimentin, CD68 (ED1) and lysozyme. We concluded that this tumor occurred in the popliteal lymph node, considering the anatomical location of the lesion and the presence of the remnants of lymphoid tissue involved in the tumor.
- 日本毒性病理学会の論文
著者
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MIYAJIMA Katsuhiro
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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KAKIMOTO Kochi
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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SHODA Toshiyuki
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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TAKAHASHI Akemi
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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Takahashi A
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Takahashi Akemi
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Kemmochi Yusuke
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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Yasui Yuzo
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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Tanoue Gimpei
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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Shoda Toshiyuki
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Toxicology Res. Laboratories Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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Miyajima Katsuhiro
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Japan Tobacco Inc. Central Pharmaceutical Research Institute Toxicology Research Laboratories
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Yasui Yuzo
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Kakimoto Kochi
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Shoda Toshiyuki
Toxicology Research Lab. Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Tanoue Gimpei
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Takahashi Akemi
Toxicology Research Lab. Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Kemmochi Yusuke
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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Shoda Toshiyuki
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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Kakimoto Kochi
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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