Histopathological Features of Diabetic Ocular Complications in the Spontaneously Diabetic Torii (SDT) Rat
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概要
- 論文の詳細を見る
The Spontaneously Diabetic Torii (SDT) rat is a novel rat model recently established for type 2 diabetes mellitus. In this report, we describe the unique histopathologic characteristics of the diabetic ocular lesions observed in both sexes in aging SDT rats. The eyes were histopathologically examined at various ages in 23 SDT rats (twelve males 39 - 70 weeks; eleven females 60 - 82 weeks). Diabetic ocular lesions included cataract, rupture of the lens, posterior vitreous detachment, proliferative retinopathy, tractional retinal detachment and iris neovascularization in all of the animals of both sexes at ages over 60 weeks. The onset of diabetes is approximately 6 months later in females than in males, however, the diabetic ocular lesions were similar in females and males at ages over 60 weeks. The impaired glucose tolerance (IGT) noted over a long period of time in females may contribute to the progressive development of the lesions.
- 日本毒性病理学会の論文
- 2007-09-30
著者
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MIYAJIMA Katsuhiro
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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SHODA Toshiyuki
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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MIYAKAWA Yoshifumi
Toxicology Research Laboratories, Central Pharmaceutical Research Institute
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SHINOHARA Masami
Planning and Development Section, CLEA Japan Inc.
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TAKAHASHI Tadakazu
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, JAPAN TOBACCO INC.
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SHINOHARA Masami
Department of Pharmcovigilance, Torii Pharmaceutical Co. Ltd.
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KAKEHASHI Akihiro
Department of Ophthalmology, Asahikawa Medical College
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Kobayashi Akio
Department Of Ophthalmology Omiya Medical Center Jichi Medical School
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Shoda Toshiyuki
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Shoda Toshiyuki
Division Of Pathology National Institute Of Health Sciences
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SHINOHARA Masami
Torii Pharmaceutical Co. Ltd.
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Miyajima Katsuhiro
Toxicology Res. Laboratories Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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Shinohara Masami
Planning And Development Section Clea Japan Inc.
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Miyakawa Yoshifumi
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Takahashi Tadakazu
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Japan Tobacco Inc. Central Pharmaceutical Research Institute Toxicology Research Laboratories
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Kakehashi Akihiro
Department Of Ophthalmology Asahikawa Medical College
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Kakehashi Akihiro
Department Of Ophthalmology Omiya Medical Center Jichi Medical School
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Koyanagi Akiharu
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Shoda Toshiyuki
Toxicology Research Lab. Central Pharmaceutical Research Institute Japan Tobacco Inc.
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