Exercise After Heparin Administration : New Therapeutic Program for Patients With Non-Option Arteriosclerosis Obliterans

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概要

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• Background A prospective study examined whether a combination of an exercise program and heparin administration improves the clinical symptoms of patients with arteriosclerosis obliterans (ASO) without an indication for surgical revascularization because of the lack of distal target vessels or other reasons such as high surgical risk or lack of a vein conduit from previous coronary artery bypass surgery. Methods and Results A total of 19 consecutive patients with symptomatic non-option ASO diagnosed by angiography were randomly assigned to 3 groups : heparin+exercise (walking for 60min after heparin injection [3,000units/day IV for 14 days], n=6), heparin administration only (n=6), and exercise only (n=7). Plasma levels of hepatocyte growth factor (HGF) were serially measured before and after intravenous administration of heparin. Ankle brachial pressure index was measured and treadmill exercise test (2.5km/h, 12% slope) was performed before the 2-week treatment, just after finishing treatment, and 12 weeks after beginning the treatment. Ophthalmic examinations, including visual acuity test, ocular fundoscopy and fluorescein angiographic fundus photography, were performed before and 12 weeks after the treatment program. In all patients, HGF levels increased more than 4-fold of the basal level at 30min after heparin injection. Maximum walking time was significantly higher in the heparin+exercise group than in the other 2 groups (p<0.05). There were no patients who showed pathological retinal angiogenesis. Conclusion The combination of an exercise program and heparin administration improves the clinical symptoms of patients with non-option ASO.

• 社団法人日本循環器学会の論文
• 2005-08-20

著者

• ISOBE Mitsuaki

  Department of Cardiovascular Medicine, Tokyo Medical and Dental University

• Yasu Takanori

  First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University

• Kubo Norifumi

  First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University

• Kawakami Masanobu

  First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University

• Yasu Takanori

  First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University

• Kakehashi Akihiro

  First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University

• Kubo Norifumi

  First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University

• Saito Muneyasu

  First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University

• Saito Muneyasu

  The Cardiovasucural Division Jichi Medical School Omiya Medical Center

• Isobe Mitsuaki

  Departement Of Cardiovascular Medicine Tokyo Medical And Dental University

• Yasu Takanori

  Department Of Clinical Pharmacology & Therapeutics University Of The Ryukyus Graduate School Of

• Hashimoto Shigemasa

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Saito Muneyasu

  First Department Of Integrated Medicine Omiya Medical Center Jichi Medical University

• Kawakami M

  First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University

• Ueba Hiroto

  Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University

• Kobayashi Nobuhiko

  First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School

• KAKEHASHI Akihiro

  Department of Ophthalmology, Asahikawa Medical College

• Kawakami Masanobu

  First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University

• Kobayashi Nobuhiko

  Department Of Medicine Jichi Medical School Omiya Medical Center

• Maejima Yasuhiro

  First Department Of Integrated Medicine Omiya Medical Center Jichi Medical School:department Of Card

• Kubo Norifumi

  Division Of Cardiovascular Medicine Department Of Integrated Medicine I Jichi Medical University Sai

• Ueba Hiroto

  First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School

• Kubo Norifumi

  Cardiovascular Division Jichi Medical University Saitama Medical Center

• Hashimoto Shigemasa

  First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School

• Saito Muneyasu

  Cardiovascular Division Department Of Integrated Medicine I

• Tada Yuuko

  Division Of Cardiology Saitama Medical Center Jichi Medical School

• Yasu Takanori

  Division Of Cardiovascular Medicine Department Of Integrated Medicine I Jichi Medical University Sai

• Kakehashi Akihiro

  Department Of Ophthalmology Asahikawa Medical College

• Yasu Takanori

  First Department Of Integrated Medicine Omiya Medical Center Jichi Medical University

• Tada Yuko

  Cardiovascular Division Department Of Medicine Jichi Medical University Saitama Medical Center

• Kanda M

  Department Of Surgical Neurology Jichi Medical School Omiya Medical Center

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