雌性SDT(Spontaneously Diabetic Torii)fattyラットの病態解析
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概要
- 論文の詳細を見る
Obesity, hyperglycemia, hyperlipidemia, and diabetes-associated complications appear at younger ages (6-8 weeks) in the male Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rat than in the male original SDT (SDT-+/+) rat. However, the incidence and progression of diabetes mellitus and diabetic complications in the female SDT-fa/fa rat have not been reported in detail. In the present study, the pathophysiological features of the female SDT-fa/fa rat were examined, and compared with those of the female SDT-+/+ rat. Female SDT-fa/fa rats showed hyperphagia, obesity, hyperglycemia, and hyperlipidemia from 5 or 6 weeks of age, and hyperinsulinemia was observed from 5 to 12 weeks. Pathological changes pancreatic islets were observed from 8 weeks. Renal function parameters, such as urine volume and urinary protein, increased from 16 weeks, and pathological findings in the renal tubule, and cataracts were also observed from 16 weeks. Increases of visceral and subcutaneous fats were obvious during the observation period. In pair-feeding with SDT-+/+ rats, SDT-fa/fa rats showed improved hyperglycemia and hypertriglycemia, but hypercholesterolemia was not entirely improved during the study period. Female SDT-fa/fa rats showed diabetes mellitus and diabetes-associated complications at young ages, and fat accumulation was remarkable. Suppression of hyperphagia in SDT-fa/fa rats was effective at improving hyperglycemia and hypertriglycemia. In conclusion, the female SDT-fa/fa rat has the potential to become an important animal model of type 2 diabetes mellitus with obesity, especially for women, for which few models currently exist.
- 社団法人 日本実験動物学会の論文
- 2010-01-01
著者
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ISHII Yukihito
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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OHTA Takeshi
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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SASASE Tomohiko
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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MORINAGA Hisayo
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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KAKUTANI Makoto
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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石井 幸仁
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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太田 毅
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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笹瀬 智彦
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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UEDA Nobuhisa
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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HATA Takahiro
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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KATSUDA Yoshiaki
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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SHINOHARA Masami
Planning and Development Section, CLEA Japan Inc.
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MATSUSHITA Mutsuyoshi
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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Masuyama Taku
Toxicology Res. Laboratories Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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SHINOHARA Masami
Torii Pharmaceutical Co. Ltd.
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Katsuda Yoshiaki
Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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Miyajima Katsuhiro
Toxicology Res. Laboratories Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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Ueda Nobuhisa
Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Shinohara Masami
Planning And Development Section Clea Japan Inc.
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Miyajima Katsuhiro
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Matsushita Mutsuyoshi
Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Morinaga Hisayo
Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Kakutani Makoto
Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Hata Takahiro
Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyajima Katsuhiro
Japan Tobacco Inc. Central Pharmaceutical Research Institute Toxicology Research Laboratories
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