Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats
スポンサーリンク
概要
- 論文の詳細を見る
Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.
著者
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Sato Eimei
Laboratory Of Animal Reproduction Graduate School Of Agricultural Science Tohoku University
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Matsushita Mutsuyoshi
Biological/pharmacological Research Laboratories Central Pharmaceutical Research Institute Japan Tob
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SASASE Tomohiko
Biological/Pharmaceutical Research Laboratories, Central Pharmaceutical Research Institute, Japan To
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OHTA Takeshi
Biological/Pharmaceutical Research Laboratories, Central Pharmaceutical Research Institute, Japan To
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Kemmochi Yusuke
Toxicology Research Laboratories Central Pharmaceutical Research Institute
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TOMIMOTO Daisuke
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
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SATO Eimei
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Faculty of Agriculture, Tohoku University, 1–1 Amamiya-machi, Tsutsumi-dori, Aoba-ku, Sendai 981–8555, Japan
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YAMAGUCHI Takayuki
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
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MERA Yasuko
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
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TADAKI Hironobu
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
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MATSUSHITA Mutsuyoshi
Biological/Pharmaceutical Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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