A New Cell Death Inhibitor, Bax-inhibiting-peptide (BIP) Derived from Ku70(Animal Biology, Animal Reproduction)
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概要
- 論文の詳細を見る
Programmed cell death (apoptosis) plays a pivotal role in the homeostasis of multicellular organisms. Bax is a key mediator of apoptosis. Apoptotic stress induces the translocation of Bax from the cytosol to mitochondria, and then Bax induces mitochondria-dependent cell death. Recently, we have found that Ku70 inhibits the translocation of Bax from the cytosol to mitochondria, suggesting that Ku70 inhibits mitochondria-dependent cell death (Sawada et al., 2003b). Moreover, we have designed a new type of cell death inhibitor, Bax-inhibiting-peptide (BIP) derived from Ku70 (Sawada et al., 2003b; Yoshida et al., 2004). We have demonstrated that BIPs inhibit the cell death induced by anti-cancer drugs, UVC irradiation, and tropic factor deprivation (Sawada et al., 2003b; Yoshida et al., 2004). BIP directly binds Bax and inhibits the cytotoxic activity of Bax. BIP may become a new tool to control degenerative diseases.ApoptosisKu70BaxBax-inhibiting-peptide (BIP)cell death inhibitor
- 東北大学の論文
- 2006-03-31
著者
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SATO Eimei
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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Sato Eimei
Laboratory Of Animal Reproduction Graduate School Of Agricultural Science Tohoku University
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YOSHIDA Tomoyuki
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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MATSUYAMA SHIGEMI
Department of Veterinary Physiology,Veterinary Medical Science,The University of Tokyo,
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Yoshida Tomoyuki
Laboratory Of Animal Reproduction Graduate School Of Agricultural Science Tohoku University
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Matsuyama Shigemi
Department Of Pharmacology School Of Medicine Case Western Reserve University Case Comprehensive Can
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