Role of the Hyaluronan Receptor CD44 during Porcine Oocyte Maturation
スポンサーリンク
概要
- 論文の詳細を見る
Previous our studies have shown that CD44, the principal receptor for hyaluronan, is present on cumulus cells during oocyte maturation. Although hyaluronan-CD44 interaction has been implicated in cumulus expansion and/or oocyte maturation, the full significance of CD44 remains unknown. The objective of the present study was to further investigate the role of CD44 in cumulus expansion and oocyte maturation in pigs. We demonstrate here in that CD44 has a key role in oocyte maturation but not in cumulus expansion. Previous studies have reported the physiological significance of cumulus expansion in oocyte maturation. However, our results suggest that cumulus expansion is a necessary condition for oocyte maturation, but that it is not sufficient on its own. Furthermore, western blot analysis demonstrated that the CD44 of the in vitro-matured cumulus-oocyte complexes (COCs) had a larger molecular weight and more terminal sialic acid, which has been proven to inhibit the hyaluronan-binding ability of the receptor, than the CD44 of the in vivo-matured COCs, indicating that the hyaluronan-CD44 interactions during in vitro maturation might be insufficient compared with those in vivo. The insufficient interactions of hyaluronan-CD44 during in vitro maturation may cause the inferior capacity of fertilization and development of oocytes matured in vitro.
- 日本繁殖生物学会の論文
著者
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SASADA Hiroshi
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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SATO Eimei
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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RODRIGUEZ-MARTINEZ Heriberto
Division of Reproduction, Faculty of Veterinary Medicine and Animal Science (FVMAS), Swedish Univers
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YOKOO Masaki
Laboratory of Animal Reproduction, Faculty of Bioresource Sciences, Akita Prefectural University
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KIMURA Naoko
Laboratory of Animal Reproduction, Faculty of Agriculture, Yamagata University
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Sato Eimei
Laboratory Of Animal Reproduction Graduate School Of Agricultural Science Tohoku University
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Abe Hiroyuki
Division Of Cardiovascular Medicine Department Of Medicine Nihon University School Of Medicine
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Yokoo M
Laboratory Of Animal Reproduction Faculty Of Bioresource Sciences Akita Prefectural University
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Kimura N
Graduate School Of Agriculture Tohoku University
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Sasada Hiroshi
Laboratory Of Animal Reproduction Department Of Animal Science Faculty Of Agriculture Tohoku Univers
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MATSUMOTO Hiromichi
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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SHIMIZU Takashi
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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Shimizu T
Univ. Occupational And Environmental Health Jpn
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Yokoo Masaki
Lab. Of Animal Reproduction Fac. Of Bioresource Sciences Akita Prefectural Univ.
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Kimura N
Laboratory Of Animal Reproduction Faculty Of Agriculture Yamagata University
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Kimura Naoko
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Matsumoto Hiromichi
Laboratory Of Animal Reproduction Graduate School Of Agricultural Science Tohoku University
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Rodriguez-martinez Heriberto
Division Of Comparative Reproduction Obstetrics And Udder Health Department Of Clinical Sciences Fac
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Shimizu T
Institute Of Agriculture And Forestry University Of Tsukuba
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Yokoo Masaki
Laboratory Of Animal Reproduction Faculty Of Bioresource Sciences Akita Prefectural University
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TUNJUNG Woro
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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Tunjung Woro
Laboratory Of Animal Reproduction Graduate School Of Agricultural Science Tohoku University Biomedic
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Abe Hiroyuki
Division Of Biofunctional Science Tohoku University Biomedical Engineering Research Organization (tu
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Matsumoto Hiromichi
Laboratory Of Animal Breeding And Reproduction Division Of Animal Science Faculty Of Agriculture Uts
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