Comparison of Metabolic Fates of Nicotinamide, NAD^+ and NADH Administered Orally and Intraperitoneally; Characterization of Oral NADH
スポンサーリンク
概要
- 論文の詳細を見る
Since NADH has been implicated in medication for some symptoms and as a possible supplement for health, we characterized the metabolic fate of NADH orally given to mice by comparing with those of nicotinamide (Nam), NAD^+ and NADH intraperitoneally or orally administered. Mice were individually housed in metabolic cages, and divided into two sets of four groups. Within each set, one group was intraperitoneally or orally administered saline and the other three groups received intraperitoneal or oral administration of a pharmacological dose of Nam, NAD^+ or NADH (5μmol/mouse). Twenty-four hour urine samples for the day before and days 1 to 4 after administration were collected and analyzed for Nam and its metabolites. When mice were administered saline alone, urinary excretion of Nam and its metabolites, such as nicotinamide N-oxide (Nam N-oxide), N^1-methylnicotinamide (MNA), N^1-methyl-2-pyridone-5-carboxamide (2-Py), and N^1-methyl-4-pyridone-3-carboxamide (4-Py), was unchanged from day 0 to day 4. Intraperitoneal injection of Nam, NAD^+ and NADH produced significant increases in urinary excretion of Nam and its metabolites. Similar results were obtained when Nam and NAD^+ were given orally. On the other hand, oral administration of NADH did not bring about an increase in urinary excretion of Nam and its metabolites, suggesting that NADH in digestive organs has been decomposed to a compound(s) that cannot yield Nam. In fact, incubation of NADH at acidic pH to mimic the stomach resulted in rapid conversion of NADH to an unknown compound. Better understanding of the fate of oral NADH is needed for its therapeutic and supplemental use.
- 日本ビタミン学会の論文
著者
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佐々木 隆造
京都大学農学部
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佐々木 隆造
京大農
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佐々木 隆造
滋賀県立大
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佐々木 隆造
滋賀県立大学 人間文化学部生活文化学科食生活専攻
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佐々木 隆造
雪印乳業
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佐々木 隆造
日本合成化学
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KIMURA Naoko
Laboratory of Animal Reproduction, Faculty of Agriculture, Yamagata University
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Shibata Katsumi
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
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Shibata Katsumi
Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U
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Kimura N
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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FUKUWATARI Tsutomu
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures
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SHIBATA Katsumi
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures
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佐々木 隆造
京都大学
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SASAKI Ryuzo
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultur
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Kimura Naoko
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Sasaki Ryuzo
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Shinagawa Rika
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Fukuwatari Tsutomu
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
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Fukuwatari Tsutomu
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Shibata Katsumi
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
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Shibata Katsumi
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Fukuwatari Tsutomu
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
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