Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters : Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)

スポンサーリンク

概要

• 論文の詳細を見る

• We have previously reported that the administration of a large amount of di(n-butyl)phthalate (DBP) increased the conversion ratio of tryptophan to niacin in rats. In the present experiment, the effect of di(2-ethylhexyl)phthalate (DEHP) on the conversion ratio and how altering the conversion ratio of tryptophan to niacin depended on the concentration of DEHP were investigated to elucidate the toxic mechanism of phthalic acid esters (PhE). Rats were fed with a diet containing 0%, 0.01%, 0.05%, 0.1%, 0.5%, 1.0%, or 3.0% DEHP for 21 days. To assess the conversion ratio of tryptophan to niacin, urine samples were collected at the last day of the experiment and measured for metabolites on the tryptophan-niacin pathway. The conversion ratio increased with increasing dietary concentration of DEHP above 0.05% ; the conversion ratio was about 2% in the control group, whereas it was 28% in the 3.0% DEHP group. It is suggested that the inhibition of a-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) by DEHP or its metabolites caused this increase in the conversion ratio. We conclude that PhE such as DEHP and DBP disturbed the tryptophan-niacin metabolism.

• 社団法人日本農芸化学会の論文
• 2002-04-23

著者

• Suzuki Yuko

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri

• Shibata Katsumi

  Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture

• Shibata Katsumi

  Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U

• FUKUWATARI Tsutomu

  Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures

• SUGIMOTO Etsuro

  Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures

• SHIBATA Katsumi

  Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures

• Sugimoto E

  Univ. Shiga Prefecture Shiga Jpn

• Suzuki Y

  Department Of Applied Biological Chemistry The University Of Tokyo

• Suzuki Yoshihito

  Dep. Of Applied Biological Chemistry Univ. Of Tokyo

• Suzuki Y

  Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control

• Sugita-konishi Yoshiko

  Department Of Veterinary Science Azabu University

• Suzuki Yoshikatsu

  Riken (the Institute Of Physical And Chemical Research)

• Suzuki Yoshihito

  The Institute Of Enology And Viticulture Yamanashi University

• Suzuki Yuko

  Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina

• Suzuki Y

  Research Institute For Bioresources Okayama University

• Fukuwatari Tsutomu

  Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture

• Fukuwatari Tsutomu

  Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures

• Shibata Katsumi

  Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures

• Fukuwatari Tsutomu

  Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th

• Suzuki Yasushi

  Department Of Agricultural Chemistry The University Of Tokyo

関連論文

• Effect of Fasting on the Urinary Excretion of Water-Soluble Vitamins in Humans and Rats
• O12-03 Intracellular dynamics of an endogenous dopaminergic neurotoxin, norsalsolinol, in PC12 cells
• Expression analysis of nitric oxide synthesis related gene in Lotus japonicus
• Symbiotic Rhizobium and Nitric Oxide Induce Gene Expression of Non-symbiotic Hemoglobin in Lotus japonicus
• Co-Regulation of Brassinosteroid Biosynthesis-Related Genes During Xylem Cell Differentiation
• Expression Pattern of the CsPK3 Auxin-Responsive Protein Kinase Gene
• CL-P1, a Newly Cloned Endothelial Cell Specific Scavenger Receptor
• Identification of a Peptide Mimic of Bioactive Gibberellins with Affinity to GA 2-Oxidase
• Sequential Regulation of Gibberellin, Brassinosteroid, and Jasmonic Acid Biosynthesis Occurs in Rice Coleoptiles to Control the Transcript Levels of Anti-Microbial Thionin Genes
• Identification of a Novel factor, Vanillyl Benzyl Ether, Which Inhibits Somatic Embryogenesis of Japanese Larch (Larix leptolepis Gordon)
• PCR Cloning and Expression of the F/10 Family Xylanase Gene from Streptomyces olivaceoviridis E-86
• Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene
• SNA-60-367 Components, New Peptide Enzyme Inhibitors of Aromatase : Structure of the Fatty Acid Side Chain and Amino Acid Sequence by Mass Spectrometry
• Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora : II. Determination of Chemical Structure
• Effects of Fatty Liver Induced by Niacin-free Diet with Orotic Acid on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
• Influence of Adenine-induced Renal Failure on Tryptophan-niacin Metabolism in Rats(Food & Nutrition Science)
• Thiadiazole carboxylic acid moiety of tiadinil, SV-03, induces systemic acquired resistance in tobacco without salicylic acid accumulation
• Salicylic Acid-Mediated Cell Death in the Arabidopsis len3 Mutant
• Identification of Three Clones Which Commonly Interact with the Kinase Domains of Highly Homologous Two Receptor-Like Kinases, RLK902 and RKL1
• Molecular Characterization of Two Highly Homologous Receptor-like Kinase Genes, RLK902 and RKL1, in Arabidopsis thaliana
• Effects of Excess Biotin Administration on the Growth and Urinary Excretion of Water-Soluble Vitamins in Young Rats
• Production of Polyhydroxybutyrate by Polycistronic Expression of Bacterial Genes in Tobacco Plastid
• An Ergosterol Peroxide, a Natural Product That Selectively Enhances the Inhibitory Effect of Linoleic Acid on DNA Polymerase β
• Galactosyldiacylglycerol, a Mammalian DNA Polymerase α-Specific Inhibitor from a Sea Alga, Petalonia bingbamiae
• The Cyanogenic Glucoside, Prunasin (D-Mandelonitrile-β-D-Glucoside), Is a Novel Inhibitor of DNA Polymerase β
• Action of a New Mammalian DNA Polymerase Inhibitor, Sulfoquinovosyldiacylglycerol
• Identification and Characterization of a Novel Human Collectin CL-K1
• Molecular Cloning of Mouse Collectin Liver 1(Biochemistry & Molecular Biology)
• Effects of Partial Suppression of Ribosomal Protein S6 on Organ Formation in Arabidopsis thaliana(Biochemistry & Molecular Biology)
• Enzymatic Synthesis of Two Ginsenoside Re-β-xylosides
• Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan
• Apoptosis Induced by Niacin-Related Compounds in K562 Cells but not in Normal Human Lymphocytes
• Apoptosis Induced by Nicotinamide-related Compounds and Quinolinic Acid in HL-60 Cells
• Relationship between Protein Intake and the Ratio of N^1-Methyl-2-pyridone-5-carboxamide and N^1-Methyl-4-pyridone-3-carboxamide to N^1-Methylnicotinamide Excretion(Food & Nutrition)
• Purification and Characterization of Recombinant Mortierella vinacea α-Galactosidases I and II Expressed in Saccharomyces cerevisiae
• Resistance to Protoporphyrinogen Oxidase-inhibiting Compound S23142 from Overproduction of Mitochondrial Protoporphyrinogen Oxidase by Gene Amplification in Photomixotrophic Tobacco Cells(Organic Chemistry)
• Intracellular targeting and distribution of protoporphyrinogen oxidase-II involved in chlorophyll and heme biosynthesis
• Purification and Properties of Protoporphyrinogen Oxidase from Spinach Chloroplasts
• Molecular characterization and subcellular localization of chloroplastic protoporphyrinogen oxidase in spinach
• Intra- and Inter-Individual Variations of Blood and Urinary Water-Soluble Vitamins in Japanese Young Adults Consuming a Semi-Purified Diet for 7 Days
• Age-Related Alterations of B-Group Vitamin Contents in Urine, Blood and Liver from Rats
• Comparison of the Effects of Di(2-ethylhexyl)phthalate, a Peroxisome Proliferator, on the Vitamin Metabolism Involved in the Energy Formation in Rats Fed with a Casein or Gluten Diet
• Comparison of Metabolic Fates of Nicotinamide, NAD^+ and NADH Administered Orally and Intraperitoneally; Characterization of Oral NADH
• Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats
• Values of Water-Soluble Vitamins in Blood and Urine of Japanese Young Men and Women Consuming a Semi-Purified Diet Based on the Japanese Dietary Reference Intakes
• The Necessity of Niacin in Rats Fed on a High Protein Diet
• Changes in the Urinary Excretion of the Metabolites of the Trytophan-Niacin Pathway during Pregnancy in Japanese Women and Rats
• Conversion Ratio of Tryptophan to Niacin in Japanese Women Fed a Purified Diet Conforming to the Japanese Dietary Reference Intakes
• Effects of Excess Nicotinamide Administration on the Urinary Excretion of Nicotinamide N-Oxide and Nicotinuric Acid by Rats
• Effects of Dietary Di(2-ethylhexyl) phthalate on the Metabolism of Tryptophan to Niacin in Mice
• Vitamin Intake in Japanese Women College Students
• Identification of a Toxic Mechanism of the Plasticizers, Phtahlic Acid Esters, which are Putative Endocrine Disrupters : Time-dependent Increase in Quinolinic Acid and Its Metabolites in Rats Fed di (2-ethylhexyl) phthalate(Food & Nutrition Science)
• Effects of Stress on the Urinary Excretory Pattern of Niacin Catabolites, the Most Reliable Index of Niacin Status, in Humans
• Growth-promoting Activity of Pyrazinoic Acid, a Putative Active Compound of Antituberculosis Drug Pyrazinamide, in Niacin-deficient Rats through the Inhibition of ACMSD Activity(Food & Nutrition Science)
• Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters : Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
• Changes of Pyridine Nucleotide Levels during Adipocyte Differentiation of Mouse 3T3-L1 Cells(Biochemistry & Molecular Biology)
• Effect of Dietary Histidine Content on the Change in Content of Skin Urocanic Acid Isomers in Hairless Mice Irradiated with Ultraviolet B
• Marked Production of Ginsenosides Rd, F_2, Rg_3, and Compound K by Enzymatic Method
• Enzymatic Preparation of Ginsenosides Rg_2, Rh_1, and F_1
• Classification of Brassinosteroid-regulated Genes Based on Expression Profiles in bril and in Response to a Protein Kinase Inhibitor, Staurosporin
• Enzymatic Phosphatidylation of Thiamin, Pantothenic Acid, and Their Derivatives
• AtFLA11, a Fasciclin-Like Arabinogalactan-Protein, Specifically Localized in Screlenchyma Cells
• Effect of Lactational Exposure to Tributyltin Chloride on Innate Immunodefenses in the F1 Generation in Mice
• Preparation of Functional Single-Chain Antibodies against Bioactive Gibberellins by Utilizing Randomly Mutagenized Phage-Display Libraries
• Identification of Peptidyl Mimics of Bioactive Gibberellin Recognized by an Antibody
• Transglucosylation Activities of Multiple Forms of α-Glucosidase from Spinach(Biochemistry & Molecular Biology)
• SNF-4794: New Enzyme Inhibitors Produced by Chaetomella sp.
• Effect of Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Susceptibility to Listeria Infection(Food & Nutrition Science)
• Expression of a Functional Single-chain Antibody against GA_ in Transgenic Tobacco
• Preparation and Application of Anti-idiotypic Antibody against Anti-gibberellin A_4 Antibody
• ENZYMIC FERULOYLATION OF ARABINOXYLAN OLIGOSACCHARIDE BY AN ENZYME EXTRACTED FROM SUSPENSION CULTURED RICE CELLS
• Structure of xylan from culms of bamboo grass (Sasa senanensis Rehd.)
• Role of Atp7b Gene in Spontaneous and N-Diethylnitrosamine-induced Carcinogenesis in a New Congenic Strain, WKAH.C-Atp7b Rats
• Characteristic and Localization of the Monitor Peptide Receptor
• Elevation of Blood NAD Level after Moderate Exercise in Young Women and Mice
• Auxin Biosynthesis Inhibitors, Identified by a Genomics-Based Approach, Provide Insights into Auxin Biosynthesis
• 23aSH-9 High energy elastic scattering of ^6He+^C in a complete expansion of the Glauber amplitude
• Defense-Related Signaling by Interaction of Arabinogalactan Proteins and β-Glucosyl Yariv Reagent Inhibits Gibberellin Signaling in Barley Aleurone Cells
• Involvement of C-22-Hydroxylated Brassinosteroids in Auxin-Induced Lamina Joint Bending in Rice
• Molybdenum and Chromium Concentrations in Breast Milk from Japanese Women
• High-Fat Diet Lowers the Nutritional Status Indicators of Pantothenic Acid in Weaning Rats
• Comparison of the Nicotinamide Catabolism among Rat Strains
• Molybdenum and Chromium Concentrations in Breast Milk from Japanese Women
• Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan
• Brz220 Interacts with DWF4, a Cytochrome P450 Monooxygenase in Brassinosteroid Biosynthesis, and Exerts Biological Activity
• Fluorometric Determination of 2-Oxoadipic Acid, a Common Metabolite of Tryptophan and Lysine, by High-Performance Liquid Chromatography with Pre-Chemical Derivatization
• Effects of Excess Biotin Administration on the Growth and Urinary Excretion of Water-Soluble Vitamins in Young Rats
• Involvement of Phosphoinositol-glycan in Induction of Differentiation, from Preadipocytes to Adipocytes, of 3T3-L1 Cells by Insulin-like Growth Factor I(Biological Chemistry)
• Recognition System for Dietary Fatty Acids in the Rat Small Intestine
• The Recognition System of Dietary Fatty Acids by the Rat Small Intestinal Cells
• Preadipocyte Growth-promoting Activity in Adipose Tissue of Various Mammalia(Biological Chemistry)
• Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats
• Increased Conversion Ratio of Tryptophan to Niacin by Dietary Di-n-butylphthalate
• Efficiency of D-Tryptophan as Niacin in Rats
• High-performance liquid chromatographic measurement of urocanic acid isomers and their ratios in naturally light-exposed skin and naturally shielded skin
• Effects of Exercise on the Metabolism of NAD in Rats
• Fluorometric determination of pantothenic acid in human urine by isocratic reversed-phase ion-pair high-performance liquid chromatography with post-column derivatization
• Vitamin Intake in Japanese Women College Students
• Effects of Stress on the Urinary Excretory Pattern of Niacin Catabolites, the Most Reliable Index of Niacin Status, in Humans
• The Urinary Excretory Ratio of Nicotinamide Catabolites Was Associated with the Conversion Ratio of Tryptophan to Nicotinamide in Growing Rats Fed a Niacin-Free 20% Casein Diet

もっと見る 閉じる

スポンサーリンク