Effects of Dietary Di(2-ethylhexyl) phthalate on the Metabolism of Tryptophan to Niacin in Mice
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概要
- 論文の詳細を見る
We have reported the effect of di(2-ethylhexyl)phthalate (DEHP) on the tryptophan (Trp)-niacin pathway in rats. To clarify the universal effect of DEHP on rodents, we studied whether DEHP also has an effect on Trp metabolism in mice. Mice were fed a niacin-free, 20% casein diet supplemented with DEHP for 21 days. Feeding with DEHP decreased the body weight gain and increased the liver weight in correlation with the dose level of DEHP. The administration of DEHP significantly increased the formation of quinolinic acid and the lower metabolites of the Trp-niacin pathway. The flux of niacin in the lower part of the Trp-niacin pathway in mice was enhanced by feeding with DEHP.
- 社団法人 日本実験動物学会の論文
- 2004-01-01
著者
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佐々木 隆造
京都大学農学部
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佐々木 隆造
京大農
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佐々木 隆造
滋賀県立大
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佐々木 隆造
滋賀県立大学 人間文化学部生活文化学科食生活専攻
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Shibata Katsumi
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
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Shibata Katsumi
Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U
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FUKUWATARI Tsutomu
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures
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SHIBATA Katsumi
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures
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佐々木 隆造
京都大学
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OHTA Mari
Laboratory of Food Wholesomeness, Department of Marine Bioresources, Faculty of Fisheries, Hokkaido
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SASAKI Ryuzo
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultur
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KITAMURA Junko
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultur
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Ohta Mari
School Of Human Cultures The University Of Shiga Prefecture
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Sasaki Ryuzo
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Shinagawa Rika
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Kitamura Junko
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Fukuwatari Tsutomu
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
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Fukuwatari Tsutomu
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Shibata Katsumi
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
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Shibata Katsumi
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Fukuwatari Tsutomu
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
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